医学创新论坛第26期

Time：2:30 PM, May 17, 2024 (Friday)

Location: Room 1322, North Tower, Basic Research Building, Capital Medical University (首都医科大学基础科研楼北楼1322会议室)

Host: Prof. Guoliang Chai (柴国梁)

     Chinese Institutes for Medical Research, Beijing

Speaker: Prof. Chong Liu (刘冲) 

Qiushi Distinguished Professor

Zhejiang University School of Brain Science and Brain Medicine

Department of Neurosurgery, the Second Affiliated Hospital of Zhejiang University

Title: Decipher the Developmental Origin of Malignant Glioma

Abstract:

Malignant glioma is one of the most lethal cancers in the central nervous system, and is currently incurable. The main research interest in the Liu laboratory is to dissect molecular and cellular mechanisms of gliomagenesis. By using cutting-edge mouse genetics, combined with other biochemical, molecular and cell biology approaches, the lab aims to address some fundamental questions in glioma biology. For instance, why does the same mutation only provoke a particular type of cell to transform, but not affect others? How do extrinsic and intrinsic cues work together to determine whether a cell stays normal, or goes awry? The lab is also interested in translating the basic cancer research into clinical applications by identifying novel therapeutic targets and treatment strategies. The pertinent findings have been published in Nature, Cell, Advanced Science, Neuro-oncology, etc.

Selected publications:

1. Chen P, Wang W, Liu R, Lyu J, Zhang L, Li B, Qiu B, Tian A, Jiang W, Ying H, Jing R, Wang Q, Zhu K, Bai R, Zeng L, Duan S, Liu C.Olfactory sensory experience regulates gliomagenesis via neuronal IGF1. Nature. 2022 Jun;606(7914):550-556.
2. Tian A, Kang B, Li B, Qiu B, Jiang W, Shao F, Gao Q, Liu R, Cai C, Jing R, Wang W, Chen P, Liang Q, Bao L, Man J, Wang Y, Shi Y, Li J, Yang M, Wang L, Zhang J, Hippenmeyer S, Zhu J, Bian X, Wang YJ, Liu C. Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting. Adv Sci (Weinh).2020 Oct 1;7(21):2001724.
3. Liu R, Jia Y, Guo P, Jiang W, Bai R, Liu C. In Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones. Adv Sci (Weinh). 2021 Oct;8(20):e2102274.