医学创新论坛第43期

CIMR Wednesday Lecture Series

时间：2024年10月16日（周三）下午4:00

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：李国民

首都医学科学创新中心

报告人：Lee Zou (邹力) 

杜克大学医学院教授

报告题目：

The ATR Checkpoint: from Basic Science to Cancer Therapy

摘要：

In proliferating cells, the integrity of the genome is consistently challenged by intrinsic and extrinsic stresses during DNA replication. Replication stress, a collection of different types of interferences with DNA replication, is a major source of genomic instability. In highly proliferative cancer cells, replication stress is elevated by oncogenic events, driving genomic instability during tumorigenesis and tumor evolution. The ATR kinase is a master regulator of the replication stress response in human cells. My lab has extensively studied how ATR is activated by replication stress and how it functions to protect replication forks under stress. In addition, our recent studies reveal that ATR is activated by different types of replication stress in cancer cells, and it plays an important role in keeping cancer cells alive under stress.

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