医学创新论坛第45期

时间：2024年11月1日（周五）下午14:30

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：邓子厚

首都医学科学创新中心

报告人：胡婧

北京大学生命科学学院研究员

报告题目：

Immune Suppressors of Dormant Metastatic Outbreaks

摘要：

Metastasis is the principal cause of death from cancer. For early-stage cancer patients, although no metastasis is detected at the time of diagnosis, metastatic relapse frequently develops after the apparently successful treatment of the primary tumor. These recurrences are thought to be due to disseminated tumor cells (DTCs) that remain dormant in distant organs until triggered to reinitiate metastatic outgrowth. DTCs fluctuate between an immune-evasive quiescent state and a proliferative state liable to immune-mediated elimination. Little is known about how immune system maintains the balance. We used in vivo CRISPR screens of tumour-intrinsic immune regulators in models of indolent lung adenocarcinoma metastasis and identified the stimulator of interferon genes (STING) pathway as a suppressor of metastatic outbreak. STING activity increases in metastatic progenitors that re-enter the cell cycle and is dampened in spontaneous metastases. STING activation in cancer cells suppresses their outgrowth in a T cell- and natural killer cell-dependent manner. Systemic treatment of mice with STING agonists eliminates dormant metastasis and prevents spontaneous outbreaks. Thus, STING provides a checkpoint against the progression of dormant metastasis and a therapeutically actionable strategy for the prevention of disease relapse.

代表性论文：