主持人：梅林

首都医学科学创新中心

报告人：Roger A. Nicoll

加州大学旧金山分校细胞与分子药理学系 教授

报告题目：

A molecular machine for memory

摘要：

CaMKII and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. Francis Crick proposed that a memory molecule should possess two properties. First, it should be a multimeric protein with identical subunits that can phosphorylate each other. Second, to address how memories outlast molecular turnover he proposed that naïve unphosphorylated subunits could exchange into the phosphorylated multimer and become phosphorylated. In my talk I will demonstrate that autophosphorylation of CaMKII, indeed, maintains LTP (memory) by the synaptic capture of AMPA receptors and that this memory survives the protein turnover of CaMKII.

代表性论文：

1. Nicoll RA. A Brief History of Long-Term Potentiation. Neuron. 2017 Jan 18;93(2): 281-290.

2. Tao W, Lee J, Chen X, Díaz-Alonso J, Zhou J, Pleasure S, Nicoll RA. Synaptic memory requires CaMKII. Elife. 2021 Dec 15;10: e60360.

3. Chen X, Cai Q, Zhou J, Pleasure SJ, Schulman H, Zhang M, Nicoll RA. CaMKII autophosphorylation is the only enzymatic event required for synaptic memory. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26): e2402783121.