器官发育再生中细胞起源与命运研究
发布时间:2025-02-26

医学创新论坛第58

 

CIMR Wednesday Lecture Series

 

时间:2025年2月26日(周三)下午16:00

 

地点:首都医科大学基础科研楼北楼一层逸夫报告厅

 

主持人:

柴国梁

首都医学科学创新中心

 

报告人:

周斌

中国科学院分子细胞科学卓越创新中心

 

报告题目:

器官发育再生中细胞起源与命运研究

 

摘要:

Recent studies of lineage tracing methodologies have revolutionized our understanding of cellular origins, fates, plasticity, and heterogeneity in organ development, regeneration, and diseases. This presentation will introduce two recently developed genetic lineage tracing approaches and research advances, giving examples of their novel applications in the study of cell origins and fate plasticity. Specifically, the dual recombinase-mediated genetic lineage tracing approach has been used to unravel regional hepatocyte proliferation in liver lobules, and also to elucidate transient hepatic progenitor cells in liver repair and regeneration. Intercellular genetic lineage tracing technology is generated to monitor cell-cell communication and contact histories in vivo, the application of which identifies the role of stem cell-contacting niche stromal cells in tissue homeostasis and diseases. This presentation will also analyze and discuss the major considerations, potential solutions, and future research directions for applying these new technologies.

 

代表性论文:

1. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12): 1488-1498.
2. He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang QD, Ji Y, Tchorz JS, Zhou B. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26; 371(6532): eabc4346.
3. Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang RA, Zhou B. Monitoring of cell-cell communication and contact history in mammals. Science. 2022 Dec 2; 378(6623): eabo5503.