医学创新论坛第60期
CIMR Wednesday Lecture Series
时间：2025年3月5日（周三）下午16:00
地点：首都医科大学基础科研楼北楼一层逸夫报告厅
主持人：
何文辉
首都医学科学创新中心
报告人：
朱冰
中国科学院生物物理研究所
报告题目：
Epigenetics: remember the past & prepare for the future
摘要：
The epigenetic system helps to fulfil two basic challenges of multicellular organisms: proliferation and differentiation. Epigenetic plasticity allows cells to differentiate, whereas epigenetic inheritance and maintenance help to maintain cell fate in proliferating cells and postmitotic cells. Interestingly, epigenetic mechanisms not only regulate gene expression at the current stage, but also regulate the kinetics of gene induction in the future, through different mechanisms in various biological processes. In this talk, I will highlight our recent discoveries regarding how epigenetic mechanisms regulate the kinetics of future gene induction in biological processes such as memory and reining.
代表性论文：
1. Ma R, Zhang Y, Zhang J, Zhang P, Liu Z, Fan Y, Wang HT, Zhang Z, Zhu B. Targeting pericentric non-consecutive motifs for heterochromatin initiation. Nature. 2024 Jul; 631(8021): 678-685.
2. Zhang J, Zhang Y, You Q, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu CP, Zhang Z, Xu RM, Zhu B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science. 2022 Mar 4; 375(6584): 1053-1058.
3. Xu M, Long C, Chen X, Huang C, Chen S, Zhu B. Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science. 2010 Apr 2; 328(5974): 94-98.
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010-86738999
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