医学创新论坛第63期

CIMR Wednesday Lecture Series

时间：2025年3月26日（周三）下午16:00

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：

孙少聪

首都医学科学创新中心

报告人：

黄波 教授

中国医学科学院北京协和医学院

报告题目：

Power of softness in mechano-onco-immunology

摘要：

Stiffness is a fundamental mechanical trait of cells, which is described as the resistance to deformation. Softness is the opposite of stiffness, consistent with cellular deformation. Cell stiffness is decided by cytoskeletons, mainly by microfilaments, having little relationship to microtubules or intermediate filaments. Adapting mechanobiology principles, we found that soft 3D fibrin gel culture system can effectively amplify stem cell-like tumor cells. Conventional surface markers are not stable; in contrast, mechanical softness is stable and can act as an ideal marker of tumor-repopulating cells or cancer stem cells. This softness can be used by tumor-repopulating cells to dampen perforin pore formation, thus evading T cell killing; however, drug-packaging microparticles use TRCs’ softness to enter TRCs and activate the lysosomal pathway to deliver drug molecules into the nucleus, inducing soft tumor cell death. Perforin pore formation is unidirectional to avoid T cell autolysis. This is because effector T cells are also very soft. Three dimension fibrin gels are suitable to amplify not only TRCs but also stem-like CAR T cells, achieving CAR T treatment of solid tumors.

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