医学创新论坛第65期
CIMR Wednesday Lecture Series
时间：2025年4月2日（周三）下午16:00
地点：首都医科大学基础科研楼北楼一层逸夫报告厅
主持人：
李国民
首都医学科学创新中心
报告人：
管坤良
讲席教授
西湖大学生命科学学院
报告题目：
The Hippo pathway in organ size control and cancer
摘要：
The seminar will review background and recent progress in the Hippo signaling field. It will also discuss the role of Hippo signaling in tumorigenesis as well as recent advance in drug development targeting the Hippo pathway for cancer treatment.
代表性论文：
1. Ma S, Wu Z, Yang F, Zhang J, Johnson RL, Rosenfeld MG, Guan KL. Hippo signalling maintains ER expression and ER+ breast cancer growth. Nature. 2021 Mar;591(7848):E1-E10.
2. Wu Z, Su J, Li FL, Chen T, Mayner J, Engler A, Ma S, Li Q, Guan KL. YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis. Nat Commun. 2023 Sep 22;14(1):5916.
3. Franklin JM, Wu Z, Guan KL. Insights into recent findings and clinical application of YAP and TAZ in cancer. Nat Rev Cancer. 2023 Aug;23(8):512-525.
北京市丰台区右安门外西头条10号
010-86738999
cimr@cimrbj.ac.cn
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