医学创新论坛第67期

CIMR Wednesday Lecture Series

时间：2025年4月23日（周三）下午16:00

地点：首都医科大学基础科研楼北楼二层多功能厅

主持人：

梁德光

首都医学科学创新中心

报告人：

岳蜀华

教授

北京航空航天大学

报告题目：

Lipid Metabolic Profiling via Quantitative Stimulated Raman Scattering Imaging Opens Up New Avenues for Precision Medicine

摘要：

Lipid droplet (LD) is a dynamic organelle closely associated with cellular functions and energy homeostasis. Dysregulated LD biology underlies an increasing number of human diseases. Commonly used lipid staining and analytical tools are difficult to provide the information regarding LD distribution and composition at the same time. To address this problem, stimulated Raman scattering (SRS) microscopy uses the intrinsic chemical contrast of biomolecules to achieve both direct visualization of LD dynamics and quantitative analysis of LD composition with high molecular selectivity at the subcellular level. Recent developments of Raman tags have further enhanced sensitivity and specificity of SRS imaging without perturbing molecular activity. Taking these advantages, SRS microscopy has offered great promise for deciphering LD metabolism in single live cells. Our work showcases the applications of SRS microscopy as an emerging platform to dissect LD biology in development and progression of human diseases. This talk will focus on the development of SRS imaging technology by our research group and its application in precision medicine.

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