医学创新论坛第76期

时间：2025年6月25日（周三）下午15:30

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：

何文辉

首都医学科学创新中心

报告人：

李斌

上海交通大学医学院

教授

报告题目：

FOXP3⁺ Regulatory T Cells and the Future of Personalized Immunotherapy

摘要：

FOXP3⁺ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. Research in our laboratory mainly focuses on understanding molecular mechanism underlying the functional instability, and imbalance of FOXP3⁺ Regulatory T cells (Treg) and RORγt⁺ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutically modulation, especially by compounds from Chinese Traditional Medicine. By using and developing Treg specifically depletion disease models, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism with clinical samples, we are revealing the functional perturbation of tissue-specific Treg subsets and mechanisms underlying their perturbation in health and disease settings. We expect that our original findings will be translational to biomedical industry and be beneficial to the future of Treg-based immunotherapy for the prevention and treatment of autoimmune diseases, graft-versus-host disease (GVHD) and inflammation-driven cancer.

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