医学创新论坛第72期
时间：2025年5月26日（周一）下午16:00
地点：首都医科大学基础科研楼北楼一层逸夫报告厅
主持人：
梅林
首都医学科学创新中心
报告人：
Gabriel Waksman
Professor
Institute of Structural and Molecular Biology
University College London
报告题目：
Structural and Molecular Biology of Conjugative DNA Transfer across Bacterial Populations
摘要：
Bacterial conjugation is the unidirectional transport of genetic materials from a donor to a recipient cell. It plays crucial roles in bacterial evolution and adaptation. It is also the principal means by which antibiotic resistance genes spread among bacterial populations. It is mediated in the donor cell by three major complexes that work in concert: a DNA-processing machinery called the relaxosome, a double-membrane spanning transfer machinery termed type 4 secretion system (T4SS), and an extracellular appendage termed pilus. For this seminar, I will focus on the recent structures of the T4SS and their impact on understanding pilus biogenesis and regulation.
代表性论文：
1. Macé K, Vadakkepat AK, Redzej A, Lukoyanova N, Oomen C, Braun N, Ukleja M, Lu F, Costa TRD, Orlova EV, Baker D, Cong Q, Waksman G. Cryo-EM structure of a type IV secretion system. Nature. 2022 Jul; 607(7917): 191-196.
3. Williams SM, Raffl S, Kienesberger S, Ilangovan A, Zechner EL, and Waksman G. Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes. Nature Communications. 2025 (In Press).
北京市丰台区右安门外西头条10号
010-86738999
cimr@cimrbj.ac.cn
En
