医学创新论坛第73期
CIMR Wednesday Lecture Series
时间：2025年5月28日（周三）下午14:00
地点：首都医科大学基础科研楼北楼一层逸夫报告厅
主持人：
梁德光
首都医学科学创新中心
报告人：
俞力
清华大学生命科学学院
教授
报告题目：
Migrasome, from basic biology to therapeutic potentials
摘要：
Cells communicate with one another by secreting and releasing proteins and vesicles, and many possess the ability to migrate. In 2015, we discovered migracytosis, a mechanism for the release of cellular contents that depends on cell migration, and identified migrasomes, the vesicular structures that facilitate this process. In this seminar, I will discuss our recent advancements in understanding the mechanisms of migrasome biogenesis and their roles in various biological processes, with a particular emphasis on the roles of migrasome in the immune system.
代表性论文：
1. Jiang D, Jiao L, Li Q, Xie R, Jia H, Wang S, Chen Y, Liu S, Huang D, Zheng J, Song W, Li Y, Chen J, Li J, Ying B, Yu L. Neutrophil-derived migrasomes are an essential part of the coagulation system. Nat Cell Biol. 2024 Jul; 26(7): 1110-1123.
2. Huang Y, Zucker B, Zhang S, Elias S, Zhu Y, Chen H, Ding T, Li Y, Sun Y, Lou J, Kozlov MM, Yu L. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug; 21(8): 991-1002.
3. Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, Chen L, Yan X, Du Y, Yu L. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan; 25(1): 24-38.
北京市丰台区右安门外西头条10号
010-86738999
cimr@cimrbj.ac.cn
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