医学创新论坛第79期
时间：2025年7月16日（周三）下午16:00
地点：首都医科大学基础科研楼北楼二层多功能厅
主持人：
孙少聪
首都医学科学创新中心
报告人：
Di Yu
Chair Professor
Frazer Institute and Child Health Research Centre
University of Queensland
报告题目：
Tfh Cells: The Architects of Adaptive Immunity
摘要：
Adaptive immunity is defined by its precision in targeting non-self antigens and its capacity for long-term protection. Follicular helper T (Tfh) cells represent the archetype of CD4+ T cell help, essential for orchestrating B cell activation and antibody production—a role first recognised in the 1960s. However, only in the past two decades have we begun to unravel the complex molecular mechanisms that govern Tfh cell differentiation and function. In this talk, I will highlight how recent discoveries in biochemical and metabolic regulation have deepened our understanding of Tfh cells as central coordinators of both humoral and cellular immunity. These insights open new avenues for optimising vaccination and advancing cancer immunotherapy.
代表性论文：
1. Yao Y, Chen Z, Zhang H, Chen C, Zeng M, Yunis J, Wei Y, Wan Y, Wang N, Zhou M, Qiu C, Zeng Q, Ong HS, Wang H, Makota FV, Yang Y, Yang Z, Wang N, Deng J, Shen C, Xia Y, Yuan L, Lian Z, Deng Y, Guo C, Huang A, Zhou P, Shi H, Zhang W, Yi H, Li D, Xia M, Fu J, Wu N, de Haan JB, Shen N, Zhang W, Liu Z, Yu D. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021 Sep;22(9):1127-1139.
2. Yu D, Walker LSK, Liu Z, Linterman MA, Li Z. Targeting TFH cells in human diseases and vaccination: rationale and practice. Nat Immunol. 2022 Aug;23(8):1157-1168.
3. Chen Z, Cui Y, Yao Y, Liu B, Yunis J, Gao X, Wang N, Cañete PF, Tuong ZK, Sun H, Wang H, Yang S, Wang R, Leong YA, Simon Davis D, Qin J, Liang K, Deng J, Wang CK, Huang YH, Roco JA, Nettelfield S, Zhu H, Xu H, Yu Z, Craik D, Liu Z, Qi H, Parish C, Yu D. Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Sci Immunol. 2023 Feb 24;8(80):eadd1728.
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