医学创新论坛第80期

时间：2025年9月5日（周五）下午16:00

地点：首都医科大学基础科研楼北楼二层多功能厅

主持人：

李川源

首都医学科学创新中心

报告人：

Don W. Cleveland 

Distinguished Professor and Chair

Department of Cellular and Molecular Medicine 

University of California, San Diego

报告题目：

TDP-43 in Neurodegeneration: phase separation, aggregation, and therapy

摘要：

In 2050, the proportion of the world's population over 60 years old will nearly double. One of the most impactful consequences of aging is the decline of cognitive functions and associated neurodegenerative diseases. TDP-43, an essential nuclear RNA binding protein, is found to mis-localize to cytoplasm and form inclusions in almost every age-dependent neurodegenerative disease, including > 90% of instances of amyotrophic lateral sclerosis, > 40% of frontal temporal dementia and Alzheimer’s disease patients. My lab has long investigated the disease mechanisms of TDP-43 proteinopathy. Our work has revealed TDP-43's essential functions in splicing and regulatory pathways that underlie the pathology's formation.

代表性论文：