医学创新论坛第83期
时间：2025年9月22日（周一）下午16:00
地点：首都医科大学基础科研楼北楼二层多功能厅
主持人：
Yuval Rinkevich
首都医学科学创新中心
报告人：
Ophir Klein, PhD, MD
Professor
Cedars-Sinai, Pediatrics
报告题目：
Development and Renewal in the Mouth and Gut
摘要：
Dr. Klein’s research focuses on understanding how organs form in the embryo and how they regenerate in the adult, with a particular emphasis on the processes underlying craniofacial and dental development and renewal, as well as understanding how intestinal stem cells and their niche enable GI tract regeneration.
代表性论文：
1. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2): 250-262.
2. Viragova S, Li D, Klein OD. Activation of fetal-like molecular programs during regeneration in the intestine and beyond. Cell Stem Cell. 2024 Jul 5; 31(7): 949-960.
3. Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD. A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 Feb 2; 30(2): 188-206.e6.
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