医学创新论坛第86期

时间：2025年11月12日（周三）下午16:00

地点：首都医科大学基础科研楼北楼二层多功能厅

主持人：

王宇涛

首都医学科学创新中心

报告人：

钟波

教授

武汉大学

报告题目：

Regulation of MITA/STING-associated autoimmunity and tumor immunity

摘要：

The adaptor protein MITA (also known as STING) critically mediates immune responses to infections, inflammation, and cancers. However, directly targeting MITA for the treatment of diseases remains challenging. We have identified multiple post-translational modifiers of MITA and characterized their roles in antiviral immunity and autoimmunity. In addition, we have developed several molecules that target the post-translational modifications of MITA to inhibit the activation of MITA and autoimmunity. In this talk, I will introduce the updated discoveries in our lab on the mechanisms and the targeted therapeutic intervention of MITA-mediated inflammation and extend to discuss the immune regulation of the tumor microenvironment.

报告人简介：

Dr. Bo Zhong received Ph.D. degree in Dr. Hong-Bing Shu’s lab at Wuhan University in 2010. From 2010 to 2013, he worked as a postdoctoral fellow in Dr. Chen Dong’s lab at MD Anderson Cancer Center, Houston, Texas. In March of 2013, he joined the faculty of College of Life Sciences of Wuhan University as an independent investigator. He is currently a full professor (tenured) of College of Life Sciences and Medical Research Institute of Wuhan University, the executive director of Frontier Science Center of Immunology and Metabolism, and an adjunct professor of the Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University. He has published more than 80 peer-reviewed papers in prestigious journals such as Nat Immunol, Immunity, JEM, Nat Cancer, Cell Res, PNAS etc. He also received a number of awards, including Gu Xiaocheng Lecture Award, AAI Laboratory Travel Grant and CST-Young Investigator Award.

Dr. Zhong’s research interest is focused on the mechanisms and targeted therapy of MITA/STING-related autoimmunity, tumorigenesis and tumor metastasis. His group has characterized several key proteins involved in and ubiquitination and deubiquitination-mediated temporal and spatial regulatory mechanisms of antiviral immune signaling and inflammation. In addition, he has demonstrated that these key molecules and mechanisms are involved in autoimmunity and tumorigenesis and that targeting these molecules effectively inhibits the progression of autoimmune diseases and cancers. These findings not only advance the understanding of inflammation and tumorigenesis, but also provide potential therapeutic strategies for the related diseases.

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