Distinguished Investigator and Director
Institute for Molecular and Cellular Therapy, Chinese Institutes for Medical Research, Beijing, China
Endowed Professor
Capital Medical University, Beijing, China
E-mail: chuanli@cimrbj.ac.cn

Education
BS, Chemistry, University of Science and Technology of China
PhD, Cancer Biology, Harvard University, USA
Postdoctoral training, Harvard university, USA

 

Other positions
Professor and Director, Division of Radiation and Cancer Biology, University of Colorado School of Medicine, Denver, CO, USA
Professor of Dermatology, Pharmacology and Cancer Biology, Vice Chair for Research in the Dept. of Dermatology, Duke University School of Medicine, USA

Research interests
Novel target discovery for cancer immunotherapy, DNA repair and cell death factors in carcinogenesis and drug resistance

Representative publications
Pan D, Bao X, Hu M, Jiao M, Li F, Li CY. SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy. Cancer Res. 2022;82(15):2748-2760.
Hu M, Zhou M, Bao X, Pan D, Jiao M, Liu X, Li F, Li CY. ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation. J Clin Invest. 2021;131(3):e139333.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY. Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. Nature. 2020;588(7839):693-698.
Liu X, He Y, Li F, Huang Q, Kato TA, Hall RP, Li CY. Caspase-3 promotes genetic instability and carcinogenesis. Mol Cell. 2015;58(2):284-96.
Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'Sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, Thorburn A, Jimeno A, Raben D, Bedford JS, Li CY. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med. 2011;17(7):860-6.