Distinguished Investigator and Director
Institute for Cancer Research, Chinese Institutes for Medical Research, Beijing, China
Endowed Professor
Capital Medical University, Beijing, China
E-mail: gmli@cimrbj.ac.cn

 

Education
BS, Biological Sciences, Wuhan University
MS, Biological Sciences, Wuhan University
PhD, Chemistry, Wayne State University, Detroit, Michigan, USA
Postdoctoral training, Duke University Medical Center, USA

Associate Editor: DNA Repair
Editorial Board: Cell Discovery, Cell Research, DNA Repair

Research interests
DNA repair in cancer and cancer therapy

 

Representative publications
Huang Y, Lu C, Wang H, Gu L, Fu YX, Li GM. DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. Nat Commun. 2023;14(1):5246.
Ortega J, Lee GS, Gu L, Yang W, Li GM. Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair. Cell Res. 2021;31(5):542-553.
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM. MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. Cancer Cell. 2021;39(1):109-121.e5.
Li F, Mao G, Tong D, Huang J, Gu L, Yang W, Li GM. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell. 2013;153(3):590-600.
Zhang Y, Yuan F, Presnell SR, Tian K, Gao Y, Tomkinson AE, Gu L, Li GM. Reconstitution of 5'-directed human mismatch repair in a purified system. Cell. 2005;122(5):693-705.