Clyde and Helen Wu Professor of Epigenomics and Molecular Biology
Institute for Cancer Genetics
Columbia University Irving Medical Center, New York City, New York, USA
E-mail: zz2401@cumc.columbia.edu

Education
PhD, University of Utah, USA
Postdoctoral training, Cold Spring Harbor Laboratories, USA

 

Research interests
Epigenetic inheritance and cancer epigenetics

Representative publications
Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff SP, Zhang Z. Asymmetric distribution of parental H3K9me3 in Sphase silences L1 elements. Nature. 2023;623(7987):643-651.
Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K, Zhang Z. Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4. Cancer Discov. 2022;12(12):2906-2929.
Gan H, Serra-Cardona A, Hua X, Zhou H, Labib K, Yu C, Zhang Z. The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands. Mol Cell. 2018;72(1):140-151.e3.
Yu C, Gan H, Serra-Cardona A, Zhang L, Gan S, Sharma S, Johansson E, Chabes A, Xu RM, Zhang Z. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands. Science. 2018 Sep 28;361(6409):1386-1389.
Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z. The histone H3.3K36M mutation reprograms the epigenome of chondroblas-tomas. Science. 2016;352(6291):1344-8.