CIMR-Songbiao Zhu

Core Facilitiy Director

Wei Shao

Songbiao Zhu

Research Group

Songbiao Zhu

zhusongbiao(at)cimrbj.ac.cn

Director of Medical Mass Spectrometry Facility

zhusongbiao(at)cimrbj.ac.cn

Ph.D. Tsinghua University, China

B.S. in Biological Sciences, Jilin University, China

Work Experience

2023.06- present

Director, Medical Mass Spectrometry Facility, CIMR, Beijing, China

2023.02-2023.05

Senior Group Leader, ICE Bioscience Inc., China

2022.07-2023.01

Senior Research Investigator, BeiGene Inc., China

2020.06-2022.06

Postdoctoral Scholar, Tsinghua University, China

Introduction

The Medical Mass Spectrometry Facility (MMSF) is an integral component of the core facilities at the Chinese Institutes for Medical Research (CIMR). It is located on lower first floor, South Tower, Basic Research Building, Capital Medical University. MMSF is currently staffed by four professional technicians and will be equipped with advanced high-resolution and high-sensitivity mass spectrometers. MMSF is dedicated to providing users with services based on mass spectrometry.

The services offered by MMSF include protein identification, quantitative proteomics, interactome analysis, phosphoproteome analysis, acetylome analysis, ubiquitinome analysis, oxidative modification analysis, metabolomics, lipidomics, and metabolic flux analysis. MMSF provides comprehensive services that span from sample preparation to data acquisition and data interpretation.

Following a user-centric approach, MMSF actively collaborates with users to develop new mass spectrometry methods tailored to individualized requirements.

Representative Publications *：Co-first author; #：Co-corresponding author

Chen X^*, Li M^*, Zhu S^*, Lu Y, Duan S, Wang X, Wang Y, Chen P, Wu J, Wu D, Feng Z, Cai G, Zhu Y, Deng H, Chen X. Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes. iScience, 2023, 26: 105961. DOI: 10.1016/j.isci.2023.105961

Zhan W, Li D, Subramanyaswamy SB, Liu YJ, Yang C, Zhang H, Harris JC, Wang R, Zhu S, Rocha H, Sherman J, Qin J, Herring M, Simwela NV, Waters AP, Sukenick G, Cui L, Rodriguez A, Deng H, Nathan CF, Kirkman LA, Lin G. Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell Chem Biol, 2023, 30: 457-469. DOI: 10.1016/j.chembiol.2023.04.006

Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H. High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Genomics Proteomics Bioinformatics, 2022, 20: 657-669. DOI: 10.1016/j.gpb.2019.12.002

Ma Y^*, Zhu S^*, Yi M, Zhang W, Xue Y, Liu X, Deng H. Profiling Glutathionylome in CD38-Mediated Epithelial-Mesenchymal Transition. J Proteome Res, 2022, 21: 1240-1250. DOI: 10.1021/acs.jproteome.1c00893

Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian X, Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X, Xiang S. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 2021, 12: 321. DOI: 10.1038/s41467-020-20538-w

Yang C^*, Zhu S^*, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H. Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med, 2021, 175: 206-215. DOI: 10.1016/j.freeradbiomed.2021.09.002

Guo J^*, Zhu S^*, Deng H, Xu R.HSP60-knockdown suppresses proliferation in colorectal cancer cells via activating the adenine/AMPK/mTOR signaling pathway. Oncol Lett, 2021, 22: 630. DOI: 10.3892/ol.2021.12891

Cao S, Chen Y, Yan Y, Zhu S, Tan Y, Wang T, Song Y, Deng H, Yang R, Du Z. Secretome and Comparative Proteomics of Yersinia pestis Identify Two Novel E3 Ubiquitin Ligases That Contribute to Plague Virulence. Mol Cell Proteomics, 2021, 20: 100066. DOI: 10.1016/j.mcpro.2021.100066

Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W, Rao Y. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem, 2019, 62: 7575-7582. DOI: 10.1021/acs.jmedchem.9b00871

Ismayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Yihao Liu A, Zhu S, Deng H, Gorovits R, Hong Y, Hanley-Bowdoin L, Liu Y. Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathog, 2018, 14: e1007282. DOI: 10.1371/journal.ppat.1007282

Full List of Publications Can Be Found Here