No. 32

Time：Wednesday, July 24, 2024, 3:00 p.m.

Location: Room 1322, North Tower, Basic Research Building, Capital Medical University 

Host：Guomin Li 

Chinese Institutes for Medical Research, Beijing

Speaker：Fen Xia

Medical Residency Director

Professor and Chair

Department of Radiation Oncology

University of Arkansas for Medical Sciences (UAMS)

TITLE：Targeting DNA damage response to enhance cancer therapeutic ratio

Dr. Xia is a radiation oncologist specializing in tumors of the central nervous system. She leads a research laboratory at the Winthrop P. Rockefeller Cancer Center, UAMS. In her laboratory, Dr. Xia works alongside other talented oncologists in pursuit of new ways to treat cancer. Dr. Xia and her team conduct federally funded research that focuses on the replication stress response and DNA damage repair mechanisms in normal and tumor cells after radiation therapy or chemotherapy. The research in Dr. Xia’s laboratory aims to understand the impact of deregulated DSB repair on carcinogenesis, tumor resistance, and normal tissue injury during cancer treatment. With the understanding of DNA repair process and its crosstalk with intracellular metabolism, and extracellular microenvironment, Dr. Xia hope to develop novel avenues for both cancer prevention and personalized cancer treatment.

SELECTED PAPERS

1. Sizemore ST, Mohammad R, Sizemore GM, Nowsheen S, Yu H, Ostrowski MC, Chakravarti A, Xia F. Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent. Mol Cancer Res. 2018 Jul;16(7):1092-1102.
2. Sizemore ST, Zhang M, Cho JH, Sizemore GM, Hurwitz B, Kaur B, Lehman NL, Ostrowski MC, Robe PA, Miao W, Wang Y, Chakravarti A, Xia F. Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair. Cell Res. 2018 Nov;28(11):1090-1102.
3. Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest.2020 Jun 1;130(6):2953-2965.