Laboratory Introduction
Dr. Shiyu Liu graduated from the School of Life Sciences at Peking University in 2016 and earned his Ph.D. degree in Computational Biology and Bioinformatics from Duke University in 2021. Following his doctoral studies, he continued as a postdoctoral researcher at Duke University. In January 2025, Dr. Liu will establish his independent laboratory at the Chinese Institute for Medical Research, Beijing (CIMR).
A. Research Direction
The laboratory will focus on metabolic flux analysis as its core technology, with the goal of developing innovative methods for deciphering metabolic activities in complex organisms. By integrating metabolic flux analysis with diverse physiological, multi-omics, and genetic technologies, the lab aims to:
1. Investigate how varying nutritional conditions influence metabolic activities across multiple organs in animals, and explore strategies for actively modulating metabolic pathways to restore or optimize dysfunctional metabolic states.
2. Utilize spatial metabolomics technologies to examine tissue-level metabolic heterogeneity, revealing the link between this heterogeneity and the normal functioning of organs.
Through these approaches, the lab aspires to quantitatively uncover the fundamental principles governing metabolic networks in living systems and design novel therapeutic strategies to address a wide range of metabolic diseases.
B. Representative Publications
Liu et al., 2020, Cell Metabolism, PMID: 32961109
Wei, Liu et al., 2024, Nature Aging, PMID: 39060538
Liu et al., 2024, Nature Metabolism, PMID: 39455888
Open position
Research Assistant
Main Responsibilities:
a. Collaborate with lab members and external software development teams to design, implement, and maintain research software, ensuring smooth execution of software engineering projects in the lab.
b. Oversee and maintain the lab’s computing infrastructure, digital resources, and cloud-based services, ensuring they meet the needs of ongoing scientific research.
c. Assist with daily laboratory operations and provide support to the team.
Qualifications:
a. Bachelor’s degree or higher in Computer Science, Software Engineering, Bioinformatics, or a related field.
b. Prior experience in software project development is required; experience with scientific computing software development is highly preferred.
c. Strong sense of responsibility, excellent communication skills, and the ability to work collaboratively in a team-oriented research environment.
Welfare Treatment
a.
Competitive Salary A highly competitive salary, commensurate with the candidate’s experience and qualifications, will be offered (details to be discussed during the interview).
b. Comprehensive Benefits
Full coverage of social insurance, paid annual leave, regular health check-ups, and supplemental medical insurance.
c.
Professional Development Opportunities for personal and professional growth, including access to job-related training programs and skill enhancement resources.
Application Process
Application Materials
Please submit a CV, a statement of research interests or plans, and the names and contact information of 2–3 referees who can attest to your research capabilities.
Submission
Email all required application materials to shiyu.liu@cimrbj.ac.cn with the subject line formatted as "[Applicant Name] + [Position Applied For]".
Contact person: Dr. Shiyu Liu
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.