CIMR-Research Progress of Stem-Cell-Derived Islet Transplantation in the Treatment of Type 1 Diabetes Mellitus

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Research Progress of Stem-Cell-Derived Islet Transplantation in the Treatment of Type 1 Diabetes Mellitus

Date：2024-12-25

NO. 54

CIMR Wednesday Lecture Series

Time:

Wednesday, Dec. 25 2024, 4:00 p.m.

Location:

Yifu Lecture Hall, North Basic Research Building

Host：

Huixia Ren (任会霞)

Chinese Institutes for Medical Research, Beijing

Speaker：

Shusen Wang (王树森)

Chief Physician

Organ Transplant Center

Tianiin First Central Hospital

Schoo of Medicine

Nankai University

TITLE：

Research Progress of Stem-Cell-Derived Islet Transplantation in the Treatment of Type 1 Diabetes Mellitus

ABSTRACT:

Islet transplantation has gradually become an ideal treatment for type 1 diabetes, but it is limited by a serious shortage of donor sources. Stem cells can be used to construct islet organoids with similar structure and function to human islets through proliferation and differentiation in vitro, so as to solve the problem of shortage of islet transplantation donors. In recent years, important progress has been made in basic research and clinical exploration of stem cell-derived islet transplantation in the treatment of type 1 diabetes.

SELECTED PAPERS

1. Wang S, Du Y, Zhang B, Meng G, Liu Z, Liew SY, Liang R, Zhang Z, Cai X, Wu S, Gao W, Zhuang D, Zou J, Huang H, Wang M, Wang X, Wang X, Liang T, Liu T, Gu J, Liu N, Wei Y, Ding X, Pu Y, Zhan Y, Luo Y, Sun P, Xie S, Yang J, Weng Y, Zhou C, Wang Z, Wang S, Deng H, Shen Z. Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell. 2024 Oct 31;187(22):6152-6164.e18.

2. Du Y, Liang Z, Wang S, Sun D, Wang X, Liew SY, Lu S, Wu S, Jiang Y, Wang Y, Zhang B, Yu W, Lu Z, Pu Y, Zhang Y, Long H, Xiao S, Liang R, Zhang Z, Guan J, Wang J, Ren H, Wei Y, Zhao J, Sun S, Liu T, Meng G, Wang L, Gu J, Wang T, Liu Y, Li C, Tang C, Shen Z, Peng X, Deng H. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat Med. 2022 Feb;28(2):272-282.