CIMR-Postdoctoral Fellows Positions in Hansen Lab

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Postdoctoral Fellows Positions in Hansen Lab

Date：2025-01-08

Laboratory Introduction

The Hansen Laboratory at CIMR focuses on studying the signaling of excitable cells in their native three-dimensional state to better understand the molecular basis of human disease. By investigating these molecular mechanisms, we aim to elucidate disease progression and develop therapies to prevent or mitigate its impact.

A. Major Research Projects

1. Establishing the molecular basis for membrane-mediated anesthesia using super-resolution imaging and spatial biology.

2. Investigating the molecular role of cholesterol in driving inflammatory diseases, including Alzheimer’s disease and chronic pain.

3. Developing non-addictive analgesics (pain medications) using novel drug discovery assays.

4. Uncovering the molecular basis of membrane-mediated mechanosensation at low thresholds.

B. Major Contributions

1. Identified a membrane-mediated mechanism of anesthetic action in mammalian cells and in fruit fly (PNAS, 2020)

2. Established a membrane-mediated mechanism of mechanosensation regulating a potassium channel (eLife, 2024; Nature Communications, 2016)

3. Identified astrocyte cholesterol as a regulator of amyloid production in Alzheimer’s Disease (PNAS, 2021)

4. Demonstrated that signaling lipids act as direct agonists of ion channels (BBA, 2016; Nature, 2011)

C. Representative Publications

eLife, 2024, 12: RP89465. DOI: 10.7554/eLife.89465

Pharmacology & Therapeutics, 2023, 249: 108486. DOI: 10.1016/j.pharmthera.2023.108486

The Journal of biological chemistry, 2023, 299: 104763. DOI: 10.1016/j.jbc.2023.104763

PNAS, 2021, 118: e2102191118. DOI: 10.1073/pnas.2102191118

PNAS, 2020, 117: 13757–13766. DOI: 10.1073/pnas.2004259117

Open position

Postdoctoral Researcher

Main Responsibilities:

a. Conduct research projects independently.

b. Assist PI to mentor graduate students, write grant proposals and manuscripts.

Qualifications:

a. Backgrounds in biology, biochemistry, or biomedical fields. A recent Ph.D. degree (ideally within the last 2 years) or about to complete a PhD.

b. Published or about to publish a first author research paper in a reputable journal.

c. Research experience in electrophysiology, super-resolution microscopy, or cryoEM is appreciated and favored.

d. Strong research experience in molecular biology, protein purification, primary cell culture, and/or mouse studies.

e. Proficient in English reading, writing, and daily communication. Capable of writing papers in English.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development and provide relevant professional guidance.

How to apply

Please send a resume, research interest or plan (for postdoc position only), the names and contacts of 2-3 referees and other materials demonstrating research capabilities to shansen@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Scott Hansen

Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing

This job posting remains open until suitable candidates are found.