CIMR-Research Position: Molecular Dynamics Simulation Specialist in Yan Lab

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Research Position: Molecular Dynamics Simulation Specialist in Yan Lab

Date：2025-02-13

Laboratory Introduction

Dr. Zhiqiang Yan obtained his bachelor's degree from Fudan University in 2004, Then, he pursued his Ph.D. degree in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, National Institute of Biology Sciences, Beijing & Institute of Biophysics, Chinese Academy of Sciences from 2004-2009. He received postdoctoral training in both Lily Jan’ group and Yuh Nung Jan’ group at Howard Hughes Medical Institute & University of California at San Francisco, San Francisco, USA. In 2013, he was appointed as a professor in Fudan University. Then, he joined Shenzhen Bay Laboratory as a senior principal investigator at 2020 and appointed as deputy director at 2022. Then, he joined Capital Medical University as the Dean and doctoral supervisor of the school of Basic Medical Sciences, and joined the Chinese Institutes for Medical Research (CIMR) in Beijing as a senior principal investigator and director of the Institute for Medical Physiology at 2024. Dr. Yan has published papers as corresponding author (including co-authors) in journals including Neuron, Nature Structural & Molecular Biology, PNAS, Nature Communications, eLife, Cell Reports, etc. He was supported by multiple projects from the National Key Research and Development Projects of China and the National Natural Science Foundation of China.

A. Research Direction

The Yan laboratory studies sensory neurobiology, focuses on identifying the receptors and neural circuits for sensation and interoception, studies their working mechanism and related the diseases in sensory system.

a. Identify the receptors for hearing, touch, pain, and thirst sensation, study the gating and assembly of the related sensory transduction complex, and explore their functions in various physiological processes, such as digestion and immunity.

b. Analysis of the protein structures of sensory receptor ion channels and their complexes, as well as the examination of ion permeability and gating mechanisms.
c. Map the critical neuronal groups and circuits for sensation and interoception such as touch, pain, vestibular and thirst sensation.
d. Study pathogenic mechanism, diagnosis and treatment of congenital hearing loss.

B. Representative Publications (corresponding author):

Neuron, 2025, 113: 411-425. PMID: 39674179

Genome Research, 2022, 32: 1573-1584. PMID: 35760561

Nature Communications, 2022, 13: 3814. PMID: 35780140

PNAS, 2021, 118: e2106459118. PMID: 34848538

eLife, 2021, 10: e58388. PMID: 34101577

Neuron, 2020, 105: 310–321. PMID: 31761710

Nature Structural & Molecular Biology, 2018, 25: 850-858. PMID: 30190597

Cell Reports, 2018, 23: 23-31. PMID: 29617663

Open position

Yan Laboratory is seeking 2 full-time researchers specializing in molecular dynamics simulations. Candidates should have a background in computational science, biology, physics, chemistry, or related fields, with a PhD or Master's degree. Positions available include Associate Researcher, Assistant Researcher, Postdoctoral Fellow, and Research Assistant, depending on research experience and educational qualifications.

PhD holders can enter the postdoctoral program, and outstanding postdoctoral fellows may be offered stable employment opportunities upon completion, with potential appointments as Assistant Researcher or Associate Researcher. The work primarily involves molecular dynamics simulations, including protein computation, simulation, and design. Applicants with relevant experimental experience are particularly welcome.

Main Responsibilities:

a. Complete molecular dynamics simulation tasks assigned by the research group.

b. Independently or collaboratively engage in molecular dynamics simulation research projects within the group.

Qualifications:

a. PhD or Master's degree in computational science, biology, physics, chemistry, or related fields.

b. Proficiency in molecular dynamics simulations.

c. Passion for scientific research, diligence, strong sense of responsibility, organizational skills, and teamwork spirit.

d. Ability to conduct independent research, strong literature reading and writing skills, high proficiency in English, and a record of high-quality publications in international academic journals in the field.

Welfare Treatment

a. Competitive salary based on the job applicant's work experience and abilities (salary negotiable).

b. Social insurance, paid annual leave, physical examination and supplementary medical insurance, etc.

c. Supporting personal career development and providing necessary job related professional training.

How to apply

To apply, please send personal resume, research interest or plan, and other materials demonstrating research capabilities to zqyan@cimrbj.ac.cn, with a copy to yan_lab@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Zhiqiang Yan

Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing

This recruitment is valid for the long term until a suitable candidate is recruited.