CIMR-Research on the Origin and Fate of Cells in Organ Development and Regeneration

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Research on the Origin and Fate of Cells in Organ Development and Regeneration

Date：2025-02-26

NO. 58

CIMR Wednesday Lecture Series

Time:

Wednesday, Feb. 26 2025, 4:00 p.m.

Location:

Yifu Lecture Hall, North Basic Research Building

Host：

Guoliang Chai (柴国梁)

Chinese Institutes for Medical Research, Beijing

Speaker：

Bin Zhou (周斌)

Professor

CAS Center for Excellence in Molecular Cell Science

TITLE：

Research on the Origin and Fate of Cells in Organ Development and Regeneration

ABSTRACT:

Recent studies of lineage tracing methodologies have revolutionized our understanding of cellular origins, fates, plasticity, and heterogeneity in organ development, regeneration, and diseases. This presentation will introduce two recently developed genetic lineage tracing approaches and research advances, giving examples of their novel applications in the study of cell origins and fate plasticity. Specifically, the dual recombinase-mediated genetic lineage tracing approach has been used to unravel regional hepatocyte proliferation in liver lobules, and also to elucidate transient hepatic progenitor cells in liver repair and regeneration. Intercellular genetic lineage tracing technology is generated to monitor cell-cell communication and contact histories in vivo, the application of which identifies the role of stem cell-contacting niche stromal cells in tissue homeostasis and diseases. This presentation will also analyze and discuss the major considerations, potential solutions, and future research directions for applying these new technologies.

SELECTED PAPERS

1. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12): 1488-1498.

2. He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang QD, Ji Y, Tchorz JS, Zhou B. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26; 371(6532): eabc4346.

3. Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang RA, Zhou B. Monitoring of cell-cell communication and contact history in mammals. Science. 2022 Dec 2; 378(6623): eabo5503.