NO. 60
CIMR Wednesday Lecture Series
Time:
Wednesday, Mar. 5 2025, 4:00 p.m.
Location:
Yifu Lecture Hall, North Basic Research Building
Host：
Wenhui He (何文辉)
Chinese Institutes for Medical Research, Beijing
Speaker：
Bing Zhu (朱冰)
Investigator
Institute of Biophysics
Chinese Academy of Sciences
TITLE：
Epigenetics: remember the past & prepare for the future
ABSTRACT:
The epigenetic system helps to fulfil two basic challenges of multicellular organisms: proliferation and differentiation. Epigenetic plasticity allows cells to differentiate, whereas epigenetic inheritance and maintenance help to maintain cell fate in proliferating cells and postmitotic cells. Interestingly, epigenetic mechanisms not only regulate gene expression at the current stage, but also regulate the kinetics of gene induction in the future, through different mechanisms in various biological processes. In this talk, I will highlight our recent discoveries regarding how epigenetic mechanisms regulate the kinetics of future gene induction in biological processes such as memory and reining.
SELECTED PAPERS
1. Ma R, Zhang Y, Zhang J, Zhang P, Liu Z, Fan Y, Wang HT, Zhang Z, Zhu B. Targeting pericentric non-consecutive motifs for heterochromatin initiation. Nature. 2024 Jul; 631(8021): 678-685.
2. Zhang J, Zhang Y, You Q, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu CP, Zhang Z, Xu RM, Zhu B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science. 2022 Mar 4; 375(6584): 1053-1058.
3. Xu M, Long C, Chen X, Huang C, Chen S, Zhu B. Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science. 2010 Apr 2; 328(5974): 94-98.
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