CIMR-Open Positions for Research Assistants in Jiang Lab

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Open Positions for Research Assistants in Jiang Lab

Date：2025-03-10

Laboratory Introduction

The Jiang lab at CIMR now has open positions for postdoctoral fellows and research assistants. The lab is dedicated to using chemical biology approaches to decode the functions of protein post-translational modifications (PTMs) in cancer and other diseases, with a focus on advancing innovative therapeutic strategies. We firmly believe science makes life better, encourage open communication, and fully support our members in learning and personal development. Our goal is to balance dedicated research with a fulfilling life. We are committed to contributing to new solutions for cancer and other diseases. If you’re after cutting-edge science mixed with a fun and supportive lab environment, read on!

Dr. Jiang graduated from Peking University with Bachelor’s and Master’s degrees under the supervision of Dr. Xiaoping Pu. He received his Ph.D. degree in Pharmacology and Molecular Sciences from the Johns Hopkins University with Dr. Philip Cole in 2022, where he studied the regulation mechanisms and substrate selectivity of HECT family E3 ligases. He then completed his postdoc training in the Cole lab at Harvard Medical School and Brigham and Women’s Hospital, where he focused on illustrating the catalytic mechanisms of HECT E3 ligases using chemical biology approaches. Dr. Jiang joined CIMR faculty in February, 2025.

A. Major Research Projects

1. Developing and applying chemical methods, such as protein semisynthesis and molecular probes, to investigate protein ubiquitination, phosphorylation, and other PTMs in key enzyme and cellular signaling pathways.

2. Exploring the regulatory mechanisms of ubiquitin and ubiquitin-like modifications and their pathological roles in disease progression to identify novel therapeutic targets.

3. Designing and optimizing synthetic biology tools for targeted ubiquitination to provide innovative methods for basic research and translational medicine.

B. Major Contributions

1. Discovered the catalytic role of terminal carboxylate involvement in ubiquitin transfer by HECT E3 ligases.

2. Uncovered the autoinhibition and activation mechanisms in HECT E3 ligases.

3. Developed a specific protein N-terminal labeling method.

C. Representative Publications

Jiang et al., 2024, Nature Chemistry, PMID:39030419

Jiang et al., 2022, JBC, PMID:35331737

Jiang et al., 2019, JBC, PMID:31578285

Dempsey, Jiang et al., 2018, JACS, PMID:30016585

Chen, Jiang et al., 2017, Molecular Cell, PMID:28475870

Open position

Research Assistant

Qualifications:

a. Bachelor’s degree or above in life sciences, chemistry, medicine, or a related field.

b. Capable of conducting research collaboratively or independently; Able to assist with daily lab operations.

c. Highly responsible, honestwitha positive mindset, and unafraid of trying new approaches.

d. Basic English communication and writing skills are required.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development, provide relevant professional guidance, and support grant or talent program applications.

How to apply

Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to hjiang@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.

Contact person: Dr. Jiang

Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing

This job posting remains open until suitable candidates are found.