CIMR-Challenges and opportunities in research of autoimmune diseases

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Challenges and opportunities in research of autoimmune diseases

Date：2025-03-12

NO. 61

CIMR Wednesday Lecture Series

Time:

Wednesday, Mar. 12 2025, 4:00 p.m.

Location:

Yifu Lecture Hall, North Basic Research Building

Host：

Chuan-Yuan Li (李川源)

Chinese Institutes for Medical Research, Beijing

Speaker：

Zhanguo Li (栗占国)

Professor

Beiling Key Laboratory for Rheumatism Mechanism and lmmune Diagnosis

Peking University People's Hospital

TITLE：

Challenges and opportunities in research of autoimmune diseases

ABSTRACT:

Autoimmune diseases are a heterogeneous group of disorder including systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis, affecting 10.1% of the population worldwide. Clinical features of these diseases are systemic organ impairments, vasculitis and destructive arthritis, associated with immune abnormality and autoantibody production. There are unmet needs in early diagnosis and rational treatment, leading to disability, and increased mortality. Recent improvement has been achieved in better understanding of molecular mechanism and development of promising therapies for these diseases. However, specific biomarkers and targeting treatments are expected clinically to improve the prognosis of these autoimmune conditions, especially in long term remission and immune homeostasis. The lecture will focus on the challenges and opportunities in research of these autoimmune diseases.

SELECTED PAPERS

1. Li C, Huang J, Wu H, Li F, Zhao Y, Zhang Z, Li S, Wei H, Zhang M, Sun H, Yang J, Li Q, Li X, Qi W, Wei W, Li Y, Li Z, Wang Y, Zhang F, Wu H, Shuai Z, Wu Z, Li Y, Jia S, Jia Y, Xiao F, Mu R, Li Z. Management of Rheumatoid Arthritis With a Digital Health Application: A Multicenter, Pragmatic Randomized Clinical Trial. JAMA Netw Open. 2023 Apr 3;6(4):e238343.

2. He J, Chu Y, Li J, Meng Q, Liu Y, Jin J, Wang Y, Wang J, Huang B, Shi L, Shi X, Tian J, Zhufeng Y, Feng R, Xiao W, Gan Y, Guo J, Shao C, Su Y, Hu F, Sun X, Yu J, Kang Y, Li Z. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Sci Adv. 2022 Feb 11;8(6):eabm1511.

3. He J, Chen J, Miao M, Zhang R, Cheng G, Wang Y, Feng R, Huang B, Luan H, Jia Y, Jin Y, Zhang X, Shao M, Wang Y, Zhang X, Li J, Zhao X, Wang H, Liu T, Xiao X, Zhang X, Su Y, Mu R, Ye H, Li R, Liu X, Liu Y, Li C, Liu H, Hu F, Guo J, Liu W, Zhang WB, Jacob A, Ambrus JL Jr, Ding C, Yu D, Sun X, Li Z. Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA Netw Open. 2022 Nov 1;5(11):e2241451.