Laboratory Introduction
The Leng Laboratory at CIMR investigates the molecular mechanisms by which FoxP3 regulates the gene network of regulatory T cells (Tregs). Our research explores multiple perspectives, including the protein interactome, three-dimensional chromatin architecture, and epigenetic modifications. Our long-term goal is to develop drugs targeting FoxP3 to modulate Treg activity, providing potential therapeutic strategies for both autoimmune diseases and cancer.
a. Exploring the molecular mechanisms of FoxP3 in regulating the gene expression in Tregs.
b. Developing small molecules, Peptides and Nanobodies to Modulate FoxP3 Function.
c. Exploring the role of microsatellites in gene regulation and genetic disorders.
a. Uncovering the critical role of FoxP3 head-to-head dimerization in Treg function (Immunity, 2022).
b. Discovering that FoxP3 recognizes and multimerizes on TnG repeat microsatellites, revealing a novel DNA-bridging mechanism (Nature, 2023).
c. Revealing the role of versatile FoxP3 ensembles in three-dimensional genomic architecture (Molecular Cell, 2025).
C. Representative Publications
Molecular Cell. 2025 (In press)
Nature. 2023 Dec; 624(7991): 433-441. PMID: 38030726
Immunity. 2022 Aug 9; 55(8): 1354-1369.e8. PMID: 35926508
Open position
Research Assistant
Main Responsibilities
a. Conducting research projects independently or in collaboration with other lab members.
b. Getting involved in lab data analysis and management.
Qualifications
a. A B.S or higher degree in biology, basic medical science and other relevant majors is required.
b. Research experience in molecular biology, biochemistry, cell biology is preferred.
c. Self-motivated researcher with good communication skill and teamwork ability.
d. Proficient in English reading, writing, and daily communication.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to fangwei.leng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.
Contact person: Dr. Leng
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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