Biological research based on large-scale multi-omics population cohorts
Date:2025-03-27

NO. 64

 

Time:

Thursday, Mar. 27 2025, 10:30 a.m.

 

Location:

Room 1322, North Basic Research Building 

 

Host

Lin Mei

Chinese Institutes for Medical Research, Beijing

 

Speaker

Yajie zhao (赵亚杰)

Principal Investigator

Changping Laboratory

 

TITLE:

Biological research based on large-scale multi-omics population cohorts

 

ABSTRACT:

Large population cohorts are the cornerstone of population-based biomedical studies. The countries including the UK, the US and Japan have invested a lot of resources on building large population cohorts and generated a lot of impactful outputs. In addition to the national efforts, the big pharma companies are highly involved in the cohort establishment, data collection and data analysis. These efforts have already been very fruitful. This talk will show how to use the data from large-scale multi-omics population cohorts to illuminate new insights into biology mechanisms and identify potential drug targets by introducing his recent work.

 

SELECTED PAPERS

1. Zhao Y, Chukanova M, Kentistou K, et al. Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nat Genet. 2024 Apr; 56(4) :579-584.
2. Zhao Y, Stankovic S, Koprulu M, et al. GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health. Nat Commun. 2021 Jul 7; 12(1): 4178.