NO. 65
CIMR Wednesday Lecture Series
Time:
Wednesday, Apr. 2 2025, 4:00 p.m.
Location:
Yifu Lecture Hall, North Basic Research Building
Host：
Guo-Min Li (李国民)
Chinese Institutes for Medical Research, Beijing
Speaker：
Kunliang Guan (管坤良)
Chair Professor
School of Life Sciences
Westlake University
TITLE：
The Hippo pathway in organ size control and cancer
ABSTRACT:
The seminar will review background and recent progress in the Hippo signaling field. It will also discuss the role of Hippo signaling in tumorigenesis as well as recent advance in drug development targeting the Hippo pathway for cancer treatment.
SELECTED PAPERS
1. Ma S, Wu Z, Yang F, Zhang J, Johnson RL, Rosenfeld MG, Guan KL. Hippo signalling maintains ER expression and ER+ breast cancer growth. Nature. 2021 Mar;591(7848):E1-E10.
2. Wu Z, Su J, Li FL, Chen T, Mayner J, Engler A, Ma S, Li Q, Guan KL. YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis. Nat Commun. 2023 Sep 22;14(1):5916.
3. Franklin JM, Wu Z, Guan KL. Insights into recent findings and clinical application of YAP and TAZ in cancer. Nat Rev Cancer. 2023 Aug;23(8):512-525.
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