NO. 71
CIMR Wednesday Lecture Series
Time:
Wednesday, May. 21 2025, 4:00 p.m.
Location:
Yifu Lecture Hall, North Basic Research Building
Host：
Kaibin Shi (史凯斌)
Chinese Institutes for Medical Research, Beijing
Speaker：
Woo-Ping Ge (戈鹉平)
Associate Investigator
Chinese Institute for Brain Research, Beijing
TITLE：
Metabolic Consumption and Production by Human Brain and Brain Tumors
ABSTRACT:
Metabolism is vital for brain function. However, a systematic investigation to understand the metabolic exchange between the human brain and circulatory system has been lacking. We compared metabolomes and lipidomes of blood samples from cerebral venous sinus and femoral artery to profile the brain’s uptake and release of metabolites and lipids (1,365 metabolites and 140 lipids). We observed a high net uptake of glucose, taurine, and hypoxanthine and identified glutamine and pyruvate as significantly released metabolites by the brain. Triacylglycerols is the most prominent class of lipid consumed by the brain. Our data also showed age-related alterations in the uptake and release of metabolites. We will also talk about some results about the metabolic exchange between brain tumors and circulatory system.
SELECTED PAPERS
1. Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F, Li F, Chen XJ, Zhang Z, Zou X, Guo Z, Zhao Y, Li JL, Ye M, Feng Z, Zhang X, Zheng L, Yu J, Li C, Tu T, Zeng H, Lei J, Zhang H, Hong T, Zhang L, Luo B, Li Z, Xing C, Jia C, Li L, Sun W, Ge WP. The subcommissural organ regulates brain development via secreted peptides. Nat Neurosci. 2024 Jun; 27(6): 1103-1115.
2. Wang Y, Zhou L, Wang N, Qiu B, Yao D, Yu J, He M, Li T, Xie Y, Yu X, Bi Z, Sun X, Ji X, Li Z, Mo D, Ge WP. Comprehensive characterization of metabolic consumption and production by the human brain. Neuron. 2025 Mar 24: S0896-6273(25)00175-8.
3. Li JL, Bi Z, Chen XJ, Ming T, Qiu B, Li F, Feng Z, Ai D, Zhang T, Wang J, Lin S, Lu Y, Wang Z, Huang J, Zhao F, Zhao H, Wang Y, Sun W, Ge WP. rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling. Nat Biomed Eng. 2025 (in press).
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