Laboratory Introduction
The Zhang laboratory develop novel computational and experimental methods to track human development, aging, and disease across time domains on single-cell, single-molecule resolution.
The laboratory conducts cross-disciplinary research with a combination of computational and experimental biological methods. We welcome colleagues with background in physics, computer science, biology, bioinformatics, and medicine to join our team.
Lab website: https://www.cimrbj.ac.cn/en/channel/1922570825047871488.html
A. Major Research Projects
The laboratory uses a combination of deep learning, bioinformatics, forward and reverse genetics, and sequencing approaches on human samples and animal models, to:
a. Develop methods to extract latent information from biological data.
b. Develop novel methods to resolve dynamic biological process from static samples.
c. Dissect the molecular mechanism of epigenome replication, particularly in aging and disease.
B. Major Contributions
a. Developed method to decode cell replicational age from single-cell ATAC-seq data (Nat.Biotech., 2024)
b. Provided evidence for how DNA secondary structure affect epigenome replication (BioRxiv, 2024)
c. Developed tools to convert Drosophila neuronal activity into genetic manipulable object (J.Neurogenetics, 2012)
C. Representative Publications
Nature Biotechnology, 2024. PMID: 38724668.
Advanced Science, 2024, 11: e2308438. PMID: 38582099.
Genome Biology, 2024, 25:117. PMID: 38715110.
Neuro-Oncology, 2022, 24: 903-913. PMID: 34918118.
Journal of Neurogenetics, 2012, 26: 89-102. PMID: 22236090.
Open position
Research Assistant
Main Responsibilities:
a. Conducting research projects either independently or in a team.
b. Assisting PI in lab routine management.
Qualifications:
a. B.S. or higher degree in biology, bioinformatics, evolutionary biology or other relevant majors is required.
b. Research experience in bioinformatics, next-generation sequencing, single-molecule sequencing (Nanopore or PacBio), cell biology and/or model animal works is preferred.
c. Self-motivated researcher with good communication skill and teamwork ability.
d. Proficient in English reading, writing, and daily communication. Passed CET 6.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhangyi@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.
Contact person: Yi Zhang
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.
Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in bioinformatics to come and exchange ideas.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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