Laboratory Introduction
The Zhang laboratory develop novel computational and experimental methods to track human development, aging, and disease across time domains on single-cell, single-molecule resolution.
The laboratory conducts cross-disciplinary research with a combination of computational and experimental biological methods. We welcome colleagues with background in physics, computer science, biology, bioinformatics, and medicine to join our team.
Lab website: https://www.cimrbj.ac.cn/en/channel/1922570825047871488.html
A. Major Research Projects
The laboratory uses a combination of deep learning, bioinformatics, forward and reverse genetics, and sequencing approaches on human samples and animal models, to:
a. Develop methods to extract latent information from biological data.
b. Develop novel methods to resolve dynamic biological process from static samples.
c. Dissect the molecular mechanism of epigenome replication, particularly in aging and disease.
B. Major Contributions
a. Developed method to decode cell replicational age from single-cell ATAC-seq data (Nat.Biotech., 2024)
b. Provided evidence for how DNA secondary structure affect epigenome replication (BioRxiv, 2024)
c. Developed tools to convert Drosophila neuronal activity into genetic manipulable object (J.Neurogenetics, 2012)
C. Representative Publications
Nature Biotechnology, 2024. PMID: 38724668.
Advanced Science, 2024, 11: e2308438. PMID: 38582099.
Genome Biology, 2024, 25:117. PMID: 38715110.
Neuro-Oncology, 2022, 24: 903-913. PMID: 34918118.
Journal of Neurogenetics, 2012, 26: 89-102. PMID: 22236090.
Open position
Postdoctoral Researcher
Main Responsibilities:
a. Conducting research projects independently.
b. Assisting PI to mentor graduate students, and write grant proposals and manuscripts.
Qualifications:
a. Backgrounds in computer science, physics, bioinformatics, biology or biomedical engineering. Either about obtaining a Ph.D. or recently obtaining a Ph.D. degree (ideally within the last 3 years).
b. Have first author paper(s) published in (or accepted by) reputable journals in the field.
c. Have the ability to independently carry out scientific research and guide graduate students, have scientific research enthusiasm and rigorous scientific research attitude.
d. Learns quickly.
e. Strong research experience in either:
(i) Perturb-seq, single-cell sequencing, single-molecule sequencing, epigenomics.
(ii) Bioinformatics, deep learning, algorithm development.
f. Proficient in English reading, writing, and daily communication.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhangyi@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.
Contact person: Yi Zhang
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.
Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in bioinformatics to come and exchange ideas.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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