No. 6

Title：Fear, Anxiety, Depression

Speaker: Xiao-Ming Li

Distinguished Professor

Institute of Neuroscience

Zhejiang University.

Host：Lin Mei

          Chinese Institutes for Medical Research

Time：10:30-11:30 am, Sep. 8, 2023 (Friday)

Location: No.78 Teaching Room, the 2^nd Teaching Building,

Capital Medical University 

Abstract：

Fear is a rapid emotional and behavioral response to danger in the environment during the process of species evolution and survival. Abnormal fear emotions can lead to various psychiatric disorders such as anxiety disorder and depression. Professor Li’s lab has long focused on fear and related psychiatric disorders. His lab has discovered multiple neural circuits and their functions and mechanisms in different phenotypes of fear and anxiety, discovered new targets for rapid regulation of anxiety and depression, and synthesized small molecule compounds targeting these new targets. Research results have been included in 20 neuroscience and psychiatry books.

References:

1. Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling. Cell Discovery. 2023, 9(1):19.
2. Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. Nature Neuroscience. 2022, 25(12):1651-1663.
3. Incerta-thalamic circuit controls nocifensive behavior via cannabinoid type 1 receptors. Neuron. 2020, 107(3):538-551.
4. Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior. Nature Medicine. 2019, 25(2):337-349.
5. A novel cortico-intrathalamic circuit for flight behavior. Nature Neuroscience. 2019, 22(6):941-949.