首都医学科学创新中心-朱松标

平台主任

邵伟

朱松标

研究人员

朱松标

zhusongbiao(at)cimrbj.ac.cn

医学质谱平台主任

zhusongbiao(at)cimrbj.ac.cn

清华大学博士

吉林大学生物科学学士

工作经历

2023.06至今

首都医学科学创新中心医学质谱平台平台主任

2023.02-2023.05

北京爱思益普生物科技股份有限公司高级组长

2022.07-2023.01

百济神州（北京）生物科技有限公司高级研究员

2020.06-2022.06

清华大学博士后

平台介绍

医学质谱平台是首都医学科学创新中心技术辅助平台的重要组成部分，位于首都医科大学南校区科研楼南楼负一层。医学质谱平台目前配备4位专业技术人员。医学质谱平台将配备先进的高分辨率和高灵敏度的质谱仪器。平台致力于为用户提供基于质谱技术的分析服务，主要包括蛋白质鉴定、定量蛋白质组学分析、相互作用蛋白组学分析、磷酸化修饰组学分析、乙酰化修饰组学分析、泛素化修饰组学分析、氧化修饰组学分析、代谢组学分析、脂质组学分析和代谢流分析。平台提供从样品前处理、上机检测和数据解析的完整服务。根据用户的个性化需求，平台积极与用户合作，开发新的质谱检测方法。

代表性文章

Chen X^*, Li M^*, Zhu S^*, Lu Y, Duan S, Wang X, Wang Y, Chen P, Wu J, Wu D, Feng Z, Cai G, Zhu Y, Deng H, Chen X. Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes. iScience, 2023, 26: 105961. DOI: 10.1016/j.isci.2023.105961

Zhan W, Li D, Subramanyaswamy SB, Liu YJ, Yang C, Zhang H, Harris JC, Wang R, Zhu S, Rocha H, Sherman J, Qin J, Herring M, Simwela NV, Waters AP, Sukenick G, Cui L, Rodriguez A, Deng H, Nathan CF, Kirkman LA, Lin G. Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell Chem Biol, 2023, 30: 457-469. DOI: 10.1016/j.chembiol.2023.04.006

Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H. High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Genomics Proteomics Bioinformatics, 2022, 20: 657-669. DOI: 10.1016/j.gpb.2019.12.002

Ma Y^*, Zhu S^*, Yi M, Zhang W, Xue Y, Liu X, Deng H. Profiling Glutathionylome in CD38-Mediated Epithelial-Mesenchymal Transition. J Proteome Res, 2022, 21: 1240-1250. DOI: 10.1021/acs.jproteome.1c00893

Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian X, Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X, Xiang S. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 2021, 12: 321. DOI: 10.1038/s41467-020-20538-w

Yang C^*, Zhu S^*, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H. Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med, 2021, 175: 206-215. DOI: 10.1016/j.freeradbiomed.2021.09.002

Guo J^*, Zhu S^*, Deng H, Xu R.HSP60-knockdown suppresses proliferation in colorectal cancer cells via activating the adenine/AMPK/mTOR signaling pathway. Oncol Lett, 2021, 22: 630. DOI: 10.3892/ol.2021.12891

Cao S, Chen Y, Yan Y, Zhu S, Tan Y, Wang T, Song Y, Deng H, Yang R, Du Z. Secretome and Comparative Proteomics of Yersinia pestis Identify Two Novel E3 Ubiquitin Ligases That Contribute to Plague Virulence. Mol Cell Proteomics, 2021, 20: 100066. DOI: 10.1016/j.mcpro.2021.100066

Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W, Rao Y. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem, 2019, 62: 7575-7582. DOI: 10.1021/acs.jmedchem.9b00871

Ismayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Yihao Liu A, Zhu S, Deng H, Gorovits R, Hong Y, Hanley-Bowdoin L, Liu Y. Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathog, 2018, 14: e1007282. DOI: 10.1371/journal.ppat.1007282

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