shaowei(at)cimrbj.ac.cn
高通量筛选平台（High Throughput Screening Facility , HTSF）是属于首都医学科学创新中心的技术辅助平台，位于首都医科大学南校区基础科研楼南楼负一层。平台将建立多种类型的化合物文库，包括FDA批准或临床化合物、已知活性化合物、结构多样性化合物、天然产物和疾病/靶点相关等化合物；同时，HTSF将配备先进的全自动高通量筛选设备，支持开发和优化多种生化或细胞水平的筛选模型，涵盖多种检测类型，包括荧光、Alpha Screen、化学发光、可见光吸收和基于图像的多指标检测等。高通量筛选平台旨在提供卓越的筛选服务，通过高效的流程和高质量的数据促进药物发现，支持内外部项目合作。
Shao W*, Li SS*, Li L, Lin KQ, Liu XH, Wang HY, Wang HL, Wang D#. Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun. Protein & Cell, 2019, 10: 161-177. DOI: 10.1007/s13238-018-0533-8
Wang YM*, Wang HY*, Shao W, Chen YH, Gui Y, Hu C, Yi XH, Huang LJ, Li SS#, Wang D#. Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer. Cancer Biology & Medicine, 2023, 21: 83-103. DOI: 10.20892/j.issn.2095-3941.2023.0276
Wang QY, Li SS, Dai YF, Yu XK, Wang YM, Li L, Yang M, Lin KQ, Shao W, Wang HY, Wang HL, Zhang GB#, Wang D#. Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy in triple negative breast cancer. BioRxiv, 2023. DOI: 10.1101/2023.03.31.535102
Yang YQ#*, Liu XH*, Guo W, Liu W, Shao W, Zhao J, Li JH, Dong Q, Ma L, He Q, Li YZ, Han JY, Lei XG#. Testing the polar auxin transport model with a selective plasma membrane H+/-ATPase inhibitor. Journal of Integrative Plant Biology, 2022, 64: 1229-1245. DOI: 10.1111/jipb.13256
Wang HY*, Li SS*, Wang QY*, Jin ZS, Shao W, Gao Y, Li L, Lin KQ, Zhu L, Wang HL, Liao XB, Wang D#. Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds. Science Advances, 2021, 7: eabd7851. DOI: 10.1126/sci adv.abd7851
Dong Q, Li X, Wang CZ, Xu SH, Yuan G, Shao W, Liu BD, Zheng Y, Wang HL, Lei XG, Zhang ZQ#, Zhu B#. Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing. Proceedings of the National Academy of Science of the United States of America, 2018, 115: E4013-E4022. DOI: 10.1073/pnas.1800505115
Li X, Shang EC, Dong Q, Li YF, Zhang J, Xu SH, Zhao ZD, Shao W, Lv C, Zheng Y, Wang HL, Lei XG, Zhu B#, Zhang ZQ#. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. Journal of Biological Chemistry, 2018, 293:7423-7436. DOI: 10.1074/jbc.RA117.000757
北京市丰台区右安门外西头条10号
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