多组学平台致力于整合前沿技术,推动生物系统复杂性研究。平台结合空间组学、靶向蛋白质组学和生物信息学,为科研人员提供强大的工具,以揭示生物过程的微观机制和动态变化。平台的核心技术:
多组学平台通过整合这些技术,为科研人员提供全面的分析工具,助力科学前沿的探索与突破。
Bao XW, Li Q, Chen D, Dai XM, Liu C, Tian WH, Zhang HY, Jin YZ, Wang Y, Cheng JL, Lai CY, Ye CQ, Xin S, Li X, Su G, Ding YF, Xiong YY, Xie JD, Tano V, Wang YG, Fu WG, Deng SG, Fang WJ, Sheng JP#, Ruan J, Zhao P. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Reports Medicine, 2024, 5(2): 101399. DOI: 10.1016/j.xcrm.2024.101399
Du J, Zhang JL, Wang L, Wang X, Zhao YX, Lu JY, Fan TM, Niu M, Zhang J, Cheng F, Li J, Zhu Q, Zhang DQ, Pei H, Li G, Liang XG, Huang H, Cao XC, Liu XJ, Shao W, Sheng JP. Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis. Nature Communications, 2023, 14(1): 3675. DOI: 10.1038/s41467-023-39173-2
Zhao YX, Song JY, Bao XW, Zhang JL, Wu JC, Wang LY, He C, Shao W, Bai XL, Liang TB, Sheng JP. Single-cell RNA sequencing-guided fate-mapping toolkit delineates the contribution of yolk sac erythro-myeloid progenitors. Cell Reports, 2023, 42(11): 113364. DOI: 10.1016/j.celrep.2023.113364
Zhang JL, Song JY, Tang SM, Zhao YX, Wang L, Luo YD, Tang JH, Ji YT, Wang X, Li TH, Zhang H, Shao W, Sheng JP#, Liang TB, Bai XL. Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation. Cell Reports, 2023, 42(6): 112620. DOI: 10.1016/j.celrep.2023.112620
Shao W, Zuo YL, Shi YY, Wu YW, Tang J, Zhao JY, Sun L, Lu ZX, Sheng JP#, Zhu Q, Zhang DQ. Characterizing the Survival-Associated Interactions Between Tumor-Infiltrating Lymphocytes and Tumors From Pathological Images and Multi-Omics Data. IEEE Transactions On Medical Imaging, 2023, 42(10): 3025-3035. DOI: 10.1109/TMI.2023.3274652
Tang JH, Sheng JP*, Zhang Q, Ji YT, Wang X, Zhang JL, Wu JC, Song JY, Bai XL, Liang TB. Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability. Journal for Immunotherapy of Cancer, 2023, 11(2): e006119. DOI: 10.1136/jitc-2022-006119
Bao XW, Li Q, Chen JZ, Chen DY, Ye CQ, Dai XM, Wang YF, Li X, Rong XX, Cheng F, Jiang M, Zhu Z, Ding YF, Sun R, Liu C, Huang LL, Jin YZ, Li B, Lu J, Wu W, Guo YX, Fu WG, Langley SR, Tano V, Fang WJ, Guo TN, Sheng JP#, Zhao P, Ruan J. Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multiomics Analysis. Cancer Immunology Research, 2022, 10(7): 811-828. DOI: 10.1158/2326-6066.CIR-21-1101
Sheng JP, Zhang JL, Wang L, Tano V, Tang JH, Wang X, Wu JC, Song JY, Zhao YX, Rong JX, Cheng F, Wang JF, Shen YN, Wen L, He JJ, Zhang H, Li TH, Zhang Q, Bai XL, Lu ZM, Liang TB. Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny. Gut, 2022, 71(6): 1176-1191. DOI: 10.1136/gutjnl-2021-324339
Sheng JP, Chen Q, Soncin I, Ng SL, Karjalainen K, Ruedl C. A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present. Cell Reports, 2017, 21(5): 1203-1214. DOI: 10.1016/j.celrep.2017.10.024
Sheng JP, Ruedl C, Karjalainen K. Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells. Immunity, 2015, 43(2): 382-393. DOI: 10.1016/j.immuni.2015.07.016