平台主任
研究人员
盛剑鹏
shengjianpeng(at)cimrbj.ac.cn
多组学平台主任
新加坡南洋理工大学 生物学 荣誉学士
新加坡南洋理工大学 免疫学 博士
工作经历
2024.08至今
首都医学科学创新中心多组学平台 平台主任
2019.07至今
浙江大学医学院附属第一医院 研究员
2014.08-2019.06
新加坡南洋理工大学 生命科学学院 研究员/资深研究员
2009.07-2010.07
新加坡基因组研究所 研究助理
平台介绍

多组学平台致力于整合前沿技术,推动生物系统复杂性研究。平台结合空间组学、靶向蛋白质组学和生物信息学,为科研人员提供强大的工具,以揭示生物过程的微观机制和动态变化。平台的核心技术:

 

1. 空间组学:空间组学结合分子生物学和成像技术,能够在单细胞水平上精确定位和分析特定分子的空间分布。该技术能够捕捉组织或器官中基因表达的空间特征,揭示细胞间相互作用、组织微环境动态变化及疾病的空间特异性。在肿瘤微环境、神经科学等领域具有广泛应用,帮助深入理解复杂的生物过程。
 
2. 靶向蛋白质组学:靶向蛋白质组学基于抗体技术,高精度定量特定蛋白质及其在不同条件下的变化。该技术能够灵敏检测低丰度生物标志物,具有高重复性和定量精度,广泛应用于生物标志物验证、新药靶标鉴定及疾病机理研究。
 
3. 生物信息学:生物信息学团队通过机器学习、统计分析和网络建模等先进手段,从海量组学数据中提取有意义的信息。整合空间组学和蛋白质组学数据,揭示不同组学层次之间的关联,加速新药研发和精准医学的进展。

 

多组学平台通过整合这些技术,为科研人员提供全面的分析工具,助力科学前沿的探索与突破。

代表性文章     *:共同第一作者; #:共同通讯作者
代表性文章 *:共同第一作者; #:共同通讯作者

Bao XW, Li Q, Chen D, Dai XM, Liu C, Tian WH, Zhang HY, Jin YZ, Wang Y, Cheng JL, Lai CY, Ye CQ, Xin S, Li X, Su G, Ding YF, Xiong YY, Xie JD, Tano V, Wang YG, Fu WG, Deng SG, Fang WJ, Sheng JP#, Ruan J, Zhao P. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Reports Medicine, 2024, 5(2): 101399. DOI: 10.1016/j.xcrm.2024.101399

Du J, Zhang JL, Wang L, Wang X, Zhao YX, Lu JY, Fan TM, Niu M, Zhang J, Cheng F, Li J, Zhu Q, Zhang DQ, Pei H, Li G, Liang XG, Huang H, Cao XC, Liu XJ, Shao W, Sheng JP. Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis. Nature Communications, 2023, 14(1): 3675. DOI: 10.1038/s41467-023-39173-2

Zhao YX, Song JY, Bao XW, Zhang JL, Wu JC, Wang LY, He C, Shao W, Bai XL, Liang TB, Sheng JP. Single-cell RNA sequencing-guided fate-mapping toolkit delineates the contribution of yolk sac erythro-myeloid progenitors. Cell Reports, 2023, 42(11): 113364. DOI: 10.1016/j.celrep.2023.113364

Zhang JL, Song JY, Tang SM, Zhao YX, Wang L, Luo YD, Tang JH, Ji YT, Wang X, Li TH, Zhang H, Shao W, Sheng JP#, Liang TB, Bai XL. Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation. Cell Reports, 2023, 42(6): 112620. DOI: 10.1016/j.celrep.2023.112620

Shao W, Zuo YL, Shi YY, Wu YW, Tang J, Zhao JY, Sun L, Lu ZX, Sheng JP#, Zhu Q, Zhang DQ. Characterizing the Survival-Associated Interactions Between Tumor-Infiltrating Lymphocytes and Tumors From Pathological Images and Multi-Omics Data. IEEE Transactions On Medical Imaging, 2023, 42(10): 3025-3035. DOI: 10.1109/TMI.2023.3274652

Tang JH, Sheng JP*, Zhang Q, Ji YT, Wang X, Zhang JL, Wu JC, Song JY, Bai XL, Liang TB. Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability. Journal for Immunotherapy of Cancer, 2023, 11(2): e006119. DOI: 10.1136/jitc-2022-006119

Bao XW, Li Q, Chen JZ, Chen DY, Ye CQ, Dai XM, Wang YF, Li X, Rong XX, Cheng F, Jiang M, Zhu Z, Ding YF, Sun R, Liu C, Huang LL, Jin YZ, Li B, Lu J, Wu W, Guo YX, Fu WG, Langley SR, Tano V, Fang WJ, Guo TN, Sheng JP#, Zhao P, Ruan J. Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multiomics Analysis. Cancer Immunology Research, 2022, 10(7): 811-828. DOI: 10.1158/2326-6066.CIR-21-1101

Sheng JP, Zhang JL, Wang L, Tano V, Tang JH, Wang X, Wu JC, Song JY, Zhao YX, Rong JX, Cheng F, Wang JF, Shen YN, Wen L, He JJ, Zhang H, Li TH, Zhang Q, Bai XL, Lu ZM, Liang TB. Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny. Gut, 2022, 71(6): 1176-1191. DOI: 10.1136/gutjnl-2021-324339

Sheng JP, Chen Q, Soncin I, Ng SL, Karjalainen K, Ruedl C. A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present. Cell Reports, 2017, 21(5): 1203-1214. DOI: 10.1016/j.celrep.2017.10.024

Sheng JP, Ruedl C, Karjalainen K. Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells. Immunity, 2015, 43(2): 382-393. DOI: 10.1016/j.immuni.2015.07.016