Laboratory Introduction
Dr. Wang’s Laboratory at CIMR is now hiring postdoctoral fellows and research assistants! The lab is dedicated to uncovering the regulatory mechanisms underlying infection, inflammation, and tumor progression, with a particular focus on the nuclear receptor (NR) family in viral infections, cancer immunity, and sex-based differences in immune responses. By integrating small-molecule drug development and synthetic biology approaches, we aim to develop and advance innovative therapeutic strategies for human diseases.
Our group pursues cutting-edge and ambitious scientific projects, backed by a well-equipped research platform, robust funding, and a collaborative, inclusive lab environment. We firmly believe that science makes life better, and we actively encourage open communication, curiosity-driven exploration, and continuous personal and professional growth. Our goal is to balance dedicated research with a fulfilling life. If you're passionate about exploring the frontiers of life science in a supportive and collaborative team, and to grow both professionally and personally, we warmly welcome you to join us!
Dr. Wang received his bachelor’s degree from Lanzhou University and his Ph.D. from Peking University, under the mentorship of Prof. Zhengfan Jiang, where he studied the regulatory mechanisms of the Caspase family in maintaining antiviral innate immune homeostasis and preserving immunological silence during apoptosis. He then completed his postdoctoral training at Harvard Medical School in the laboratory of Drs. Christophe Benoist and Diane Mathis, where he employed an in vivo Rainbow-CRISPR screening system to investigate the roles of nuclear receptors in immune cell differentiation and cell fate decisions. Dr. Wang will officially join the CIMR as an Assistant Investigator in June 2025.
A. Major Research Projects
a. Exploring the functions of nuclear receptors in viral infection-induced metabolic reprogramming and innate immune responses.
b. Dissecting the functions of nuclear receptors in tumor progression and immune regulation.
c. Uncovering the roles of nuclear receptors in sex-based differences in immune responses.
d. Targeting disease-specific transcriptional activity for precision therapy using synthetic biology approaches.
B. Major Contributions
a. Developed an innovative in vivo Rainbow-CRISPR screening platform and systematically investigated the nuclear receptor family in the differentiation and homeostatic control of 28 immune cell types, revealing that retinoic acid receptors regulate the fate of GATA6+ large peritoneal macrophages via transcriptional control of cell differentiation and inflammasome-mediated control of cell death (Immunity, 2024, first author).
b. Discovered a novel TRAF6-mediated Lys6-linked polyubiquitination of ASK1, which plays a pivotal role in of hepatic inflammation and fibrosis (Hepatology, 2019，first author); and identified NLK as a key suppressor of hepatic glucose production by inhibiting gluconeogenesis (Cell Metabolism, 2021, first author).
c. Identified the critical roles of the Caspase family in maintaining antiviral innate immune homeostasis and preserving immunological silence during apoptosis (Immunity, 2017, first author; Molecular Cell, 2019, co-first author).
C. Representative Publications
Wang et al., 2024, Immunity, PMID: 39571575
Ji, Wang et al., 2021, Cell Metabolism, PMID: 33951476
Wang et al., 2020, Hepatology, PMID: 31222801
Ning, Wang et al., 2019, Molecular Cell, PMID: 30878284
Wang et al., 2017, Immunity, PMID: 28314590
Open position
Research Assistant
Main Responsibilities
a. Support research projects independently or in collaboration with lab members.
b. Assist with daily lab operations, including the management of supplies and ordering of reagents.
Qualifications
a. Bachelor’s degree or above in immunology, oncology, molecular and cellular biology, or related fields.
b. Prior research experience in molecular biology and cell culture is preferred.
c. Self-motivated researcher with strong sense of responsibility, good communication skills, and teamwork ability.
d. Basic proficiency in English communication and scientific writing.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to wangyutao@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.
Contact person: Dr. Wang
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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