NO. 72
Time:
Monday, May. 26 2025, 4:00 p.m.
Location:
Yifu Lecture Hall, North Basic Research Building
Host：
Lin Mei (梅林)
Chinese Institutes for Medical Research, Beijing
Speaker：
Gabriel Waksman
Professor
Institute of Structural and Molecular Biology
University College London
TITLE：
Structural and Molecular Biology of Conjugative DNA Transfer across Bacterial Populations
ABSTRACT:
Bacterial conjugation is the unidirectional transport of genetic materials from a donor to a recipient cell. It plays crucial roles in bacterial evolution and adaptation. It is also the principal means by which antibiotic resistance genes spread among bacterial populations. It is mediated in the donor cell by three major complexes that work in concert: a DNA-processing machinery called the relaxosome, a double-membrane spanning transfer machinery termed type 4 secretion system (T4SS), and an extracellular appendage termed pilus. For this seminar, I will focus on the recent structures of the T4SS and their impact on understanding pilus biogenesis and regulation.
SELECTED PAPERS
1. Macé K, Vadakkepat AK, Redzej A, Lukoyanova N, Oomen C, Braun N, Ukleja M, Lu F, Costa TRD, Orlova EV, Baker D, Cong Q, Waksman G. Cryo-EM structure of a type IV secretion system. Nature. 2022 Jul; 607(7917): 191-196.
3. Williams SM, Raffl S, Kienesberger S, Ilangovan A, Zechner EL, and Waksman G. Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes. Nature Communications. 2025 (In Press).
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
中文
