Laboratory Introduction
The Deng Laboratory at CIMR has open positions for postdoctoral fellows and research assistants. The laboratory primarily utilizes deep immunophenotyping, single-cell and spatial multi-omics platforms, cell & molecular biology techniques, as well as genetic animal models to investigate the role of B cell heterogeneity in tumor development, metastasis and immunotherapy response. The goal is to gain a deeper understanding of the pathological mechanism of B cells in tumorigenesis and autoimmune diseases, and to further explore potential therapeutic strategies for reprogramming B cell fate. Dr. Deng graduated from the School of Life Sciences of Soochow University and received his doctorate degree from Shanghai Jiao Tong University School of Medicine. Dr. Deng has worked as postdoctoral researcher at internationally renowned research institutions, such as Chinese National Human Genome Center at Shanghai, Baylor College of Medicine and the University of Texas MD Anderson Cancer Center. Dr. Deng has been a CIMR faculty member since March 2025.
Characterizing B lymphocytes and tertiary lymphoid structures (TLSs) in the tumor microenvironment, gaining insights into the pathological mechanisms of molecular biological events that regulates B cell fate in tumorigenesis and autoimmune diseases, and providing potential therapeutic strategies.
a. Molecular mechanisms regulating the germinal center-dependent / independent responses of tumor-infiltrating B cells.
b. Mechanisms of B cell maturation and selection in tertiary lymphoid structures.
c. Identification of molecular targets that reprogram B cell fate.
a. Uncovered mutated genes of SWI/SNF chromatin remodeling complex and its molecular mechanisms regulating on malignant characteristics and fate determination of tumor cells (Cancer Cell 2024, PMID: 38458188 & PMID: 38458187; Nature Genetics 2012, PMID: 22922871).
b. Identified cellular / molecular features that associated with efficacy and toxicity of CD19 CAR-T cell therapy in relapsed or refractory large B-cell lymphoma (Cell Reports Medicine 2023, PMID: 37586321; Cancer Cell 2023, PMID: 37738975; Blood Advances 2023, PMID: 37389847; Nature Medicine 2020, PMID: 33020644).
c. Characterized tumor microenvironment of different subtypes of B-cell lymphoma, specifically found biological features associated with CD19 CAR-T cell therapy, tumor cell mutation, and antigen presentation (Cancer Cell, Under Review; Blood Cancer Discovery 2022, PMID: 35687817).
Open position
Postdoctoral Researcher
Main Responsibilities
a. Independently conduct research projects under the guidance of the PI.
b. Mentor junior lab members to carry out experiments.
c. Write manuscripts and grant proposals.
Qualifications
a. Background in life sciences or biomedical fields. Either about to obtain a Ph.D. or recently obtained a Ph.D. degree (preferably within the past 2 years).
b. Published or submitted research papers as (co-) first author in reputable journals in the field, with motivation and ability to independently carry out research work.
c. Research experiences in immunology, mouse model, multi-omics data analysis are preferred.
d. Proficient in English reading, writing and daily communication.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please combine your CV, one-page personal statement, contact information of no less than two referees and a 1-2 page research summary and interests (for postdoc applicant only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to qdeng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name” in the email subject. Application review will begin on a rolling basis and qualified applicants will be invited for interview.
Contact person: Dr. Qing Deng
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This job posting remains open until suitable candidates are found.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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