Laboratory Introduction
Dr. You is currently an Investigator at CIMR and Associate Director of the Chinese Institute for Cancer Research within CIMR. Prior to joining CIMR in 2025, he was a tenured professor at Washington University in St. Louis, School of Medicine. The You lab at CIMR investigates the molecular mechanisms of genome maintenance, RNA surveillance, and innate immunity, with the overarching goal of advancing cancer and autoimmune disease treatment. We integrate cell biology, structural biology, drug screening, and animal models to drive these studies.
Major Research Projects
The laboratory focuses on the following key research areas:
a. Intersection of DNA/RNA surveillance with innate immunity
b. Emerging roles of ions and ion channels in regulating cGAS/STING innate immune signaling
c. Therapeutic targeting of the TRPV2-STING axis in cancer and autoimmunity
d. Exploiting NMD vulnerability in spliceosome-mutant cancers
Major Contributions
a. Discovered a novel cytosolic DNA-elicited, Ca2+-mediated signaling pathway that safeguards DNA replication forks to preserve genome stability. (Mol Cell, 2019; Mol Cell 2023; Nat Commun, 2024)
b. Uncovered a novel interplay on the endoplasmic reticulum between the ion channel TRPV2 and the innate immune sensor STING, revealing a new mechanism for the co-regulation of Ca2+ dynamics and immune activation. (Mol Cell 2023; Cell Rep, accepted)
c. Pioneered the development of NMD reporter systems, enabling the identification of novel NMD inhibitors and genetic regulators, and demonstrated that NMD is modulated by intracellular Ca2+ and persistent DNA damage. (Nat Med 2014; JBC 2017)
d. Established NMD as a promising therapeutic target for cancers harboring spliceosome mutations. (Cancer Res 2021, Cancer Res, in review)
Representative Publications
Nature Communications, 2024, doi: 10.1038/s41467-024-48988-6. PMID: 38816425.
Molecular Cell, 2023, doi: 10.1016/j.molcel.2022.12.034. PMID: 36696898.
Molecular Cell, 2019, doi: 10.1016/j.molcel.2019.04.003. PMID: 31053472.
Cancer Research, 2021, doi: 10.1158/0008-5472.CAN-20-4016. PMID: 34215620.
Nature Medicine, 2014, doi: 10.1038/nm.3620. PMID: 25064126.
Laboratory website: https://www.cimrbj.ac.cn/en/channel/1972181105834594304.html
Open Positions: Research Associate Investigator/Research Assistant Investigator
Main Responsibilities
a. Conduct research independently under the guidance of the PI.
b. Assist in supervising graduate students and in writing research papers and grant proposals.
Qualifications
a. A Ph.D. in cell biology, bioinformatics, structural biology or related fields, with at least 3 years of postdoctoral research experience.
b. A strong publication record, evidenced by first-author publications in reputable journals.
c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.
d. High proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zyou@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.
Contact person: Prof. Zhongsheng You
This recruitment is valid for the long term until a suitable candidate is recruited.
Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
中文
