The Guo laboratory at CIMR works on uncovering the molecular and genetic mechanisms that regulate tissue growth and organ size control, as well as understanding how dysregulation of these processes contributes to human diseases.
Major Research Projects:
The Guo lab will use various model systems and integrate cutting-edge techniques in genetics, cell biology, and bioinformatic, with the aims of elucidating fundamental biological principles and identifying novel pathways involved in disease pathogenesis.
a. Conducting genome-wide screening in Drosophila and mouse models to identify key genes that regulate tissue growth and organ size.
b. Investigating the role of tissue mechanics in regulating tissue growth and how physical forces and mechanical properties influence cellular behavior. Additionally, we explore how the tumor microenvironment's physical properties affect tumor growth and immune response.
c. Investigating the role of the Hippo signaling pathway in normal developmental processes and how its disruption contributes to congenital developmental diseases, with a particular focus on neurodevelopmental disorders.
Representative Publications:
Science. 2024. 385(6709):eadf4478. PMID: 39116228.
eLife. 2019. 22:8:e38843. PMID: 30901309.
PNAS. 2010. 107(42):18016–18021. PMID: 20921409.
Open Positions: Research Assistant
Main Responsibilities:
a. Assist the PI with lab management and administrative tasks.
b. Assist the team in conducting research projects.
Qualifications:
a. B.S or higher degree in biology, basic medical science and other relevant majors.
b. Good communication skill and teamwork ability.