NO. 73
CIMR Wednesday Lecture Series
Time:
Wednesday, May. 28 2025, 2:00 p.m.
Location:
Yifu Lecture Hall, North Basic Research Building
Host：
Deguang Liang (梁德光)
Chinese Institutes for Medical Research, Beijing
Speaker：
Li Yu (俞力)
Professor
School of Life Sciences
Tsinghua University
TITLE：
Migrasome, from basic biology to therapeutic potentials
ABSTRACT:
Cells communicate with one another by secreting and releasing proteins and vesicles, and many possess the ability to migrate. In 2015, we discovered migracytosis, a mechanism for the release of cellular contents that depends on cell migration, and identified migrasomes, the vesicular structures that facilitate this process. In this seminar, I will discuss our recent advancements in understanding the mechanisms of migrasome biogenesis and their roles in various biological processes, with a particular emphasis on the roles of migrasome in the immune system.
SELECTED PAPERS
1. Jiang D, Jiao L, Li Q, Xie R, Jia H, Wang S, Chen Y, Liu S, Huang D, Zheng J, Song W, Li Y, Chen J, Li J, Ying B, Yu L. Neutrophil-derived migrasomes are an essential part of the coagulation system. Nat Cell Biol. 2024 Jul; 26(7): 1110-1123.
2. Huang Y, Zucker B, Zhang S, Elias S, Zhu Y, Chen H, Ding T, Li Y, Sun Y, Lou J, Kozlov MM, Yu L. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug; 21(8): 991-1002.
3. Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, Chen L, Yan X, Du Y, Yu L. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan; 25(1): 24-38.
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