The 2025 CIMR International Medical Summit was recently successfully held in Beijing. This year's summit featured leading scientists, clinicians, and industry pioneers. Under the theme "Breakthroughs in Medical Research and Innovation", this year’s summit delved into five cutting-edge areas through specialized forums: "Replication Stress and DNA Damage Response", "DNA Damage Response and Cancer Therapy", "Immune Regulation in Health & Disease", "Cell & Gene Therapy Innovations" and "Artificial Intelligence & Digital Medicine".

Over the two-day event, 27 leading scholars from around the world shared their latest research findings. The presentations covered significant breakthroughs in basic research as well as innovative applications in clinical translation, highlighting the substantial impact of interdisciplinary collaboration in driving medical innovation.

Guo-Min Li delivered the opening remarks

Rodney Rothstein: Replication stress promotes mitotic recombination, loss of heterozygosity and aneuploidy in Saccharomyces cerevisae

Xiaodong Zhang: Structures and mechanisms of RAD51 modulators

Vincenzo Costanzo: The expanding roles of homologous recombination proteins in genome stability

Stephen Kowalczykowski: Roles of BRCA1, BRCA2, and RAD51 paralogs in recombinational DNA repair

Weihang Chai: Genome instability in carcinogenesis

Zhongsheng You: TRPV2/STING interplay: genome maintenance and immune signaling

Lee Zou: Targeting the ATR checkpoint in cancer therapy

Shan Zha: Understanding the toxicity of PARP inhibitors

Yaping Huang: Heat shock protein DNAJA2 in genome maintenance and cancer therapy

Bing Xia: Maintainence of the G2/M checkpoint by the BRCA1-PALB2-BRCA2 axis

Eric Greer: The histone mimetic NOP16 promotes breast cancer

Huadong Pei: Dysregulation of de novo nucleotide synthesis and cancer

Lin Deng: Chromocytosis: a new form of genome instability

Sankar Ghosh: Noncoding RNA regulators of the immune and inflammatory responses

Chen Dong: Regulation of T cell activation and function in cancer

Ming Li: Immunological mechanisms of cancer defense

Yang-Xin Fu: Next generation of mRNA vaccination for cancer therapy

Di Yu: Your T cells are what you eat

Gensheng Feng: Efficacious suppression of liver tumors by polyIC-loaded lipid nanoparticles

Xin Lin: Developing TCR-based chimeric antigen receptor STAR for immunotherapy

Bing Du: Harnessing gene editing to develop the next generation of CAR-T cells

Yi Shi: Comprehensive structural maps of antibody repertoires accelerate therapeutic design

Qing Richard Lu: Paving the axonal highway for CNS repair

Yuji Ke: Sample-in, library-out: an AI-assisted automation platform for single-cell workflows

Junqiang Wang: Establishment and demonstration of a precision treatment system for orthopedic surgical robots

Jing Zhang: Enhanced biomimic bone implants with digital structure

Juanni Gong: From clinical issues to artificial intelligence applications in pulmonary vascular disease

Chuan-Yuan Li gave the closing remarks