NO. 76

 CIMR Wednesday Lecture Series

Time:

Wednesday, June. 25 2025, 3:30 p.m.

Location:

Yifu Lecture Hall, North Basic Research Building 

Host：

Wenhui He (何文辉)

Chinese Institutes for Medical Research, Beijing

Speaker：

Bin Li (李斌)

Distinguished Professor

Shanghai Jiao Tong University School of Medicine

TITLE：

FOXP3⁺ Regulatory T Cells and the Future of Personalized Immunotherapy

ABSTRACT:

FOXP3⁺ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. Research in our laboratory mainly focuses on understanding molecular mechanism underlying the functional instability, and imbalance of FOXP3⁺ Regulatory T cells (Treg) and RORγt⁺ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutically modulation, especially by compounds from Chinese Traditional Medicine. By using and developing Treg specifically depletion disease models, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism with clinical samples, we are revealing the functional perturbation of tissue-specific Treg subsets and mechanisms underlying their perturbation in health and disease settings. We expect that our original findings will be translational to biomedical industry and be beneficial to the future of Treg-based immunotherapy for the prevention and treatment of autoimmune diseases, graft-versus-host disease (GVHD) and inflammation-driven cancer.

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