NO. 80

Time:

Friday, September. 5 2025, 4:00 p.m.

Location:

Multi-Function Hall, 2nd Floor, North Basic Research Building 

Host：

Chuan-Yuan Li (李川源)

Chinese Institutes for Medical Research, Beijing

Speaker：

Don W. Cleveland 

Distinguished Professor and Chair

Department of Cellular and Molecular Medicine 

University of California, San Diego

TITLE：

TDP-43 in Neurodegeneration: phase separation, aggregation, and therapy

ABSTRACT:

In 2050, the proportion of the world's population over 60 years old will nearly double. One of the most impactful consequences of aging is the decline of cognitive functions and associated neurodegenerative diseases. TDP-43, an essential nuclear RNA binding protein, is found to mis-localize to cytoplasm and form inclusions in almost every age-dependent neurodegenerative disease, including > 90% of instances of amyotrophic lateral sclerosis, > 40% of frontal temporal dementia and Alzheimer’s disease patients. My lab has long investigated the disease mechanisms of TDP-43 proteinopathy. Our work has revealed TDP-43's essential functions in splicing and regulatory pathways that underlie the pathology's formation.

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