1. Deciphering the Genetic and Pathogenic Landscape of Neurological Diseases

Our research utilized whole-genome sequencing, familial genetics, and GWAS to unearth novel pathogenic genes and risk variants linked to rare and complex nervous system diseases. Employing an arsenal of gene editing tools, mouse models, stem cells, and human brain organoids, alongside multi-omics and state-of-the-art methodologies, we aim to reveal the functions and pathological mechanisms of key genetic players in these conditions.

With a focus on neuroimmune dysregulation and inflammation in neurological disorders, our approach integrates the use of genetically engineered mice tools, pioneering technologies, and patient-derived samples. This strategy enables us to dissect the intricate involvement of glial cells, cerebral lymphatic cells, and peripheral immune cells in the immune response, inflammation, and neural damage and repair processes in afflictions such as stroke, multiple sclerosis, and neurodegenerative diseases.

Our commitment to combating both rare and common neurological disorders drives us to pioneer novel therapeutic avenues and technologies. Our work is centered on the development of targeted small-molecule drugs/metabolites, monoclonal antibodies, and advanced cell and gene therapies specifically designed to address the unique challenges of the central nervous system.