The Li laboratory investigates the physiological homeostasis of key organelles, including lysosomes, the endoplasmic reticulum, mitochondria, and the Golgi apparatus, with a particular focus on the mechanisms that maintain organellar ion homeostasis. Recent research focuses the role of organellar ion channels in neurodegenerative diseases, cardiac function, and metabolic disorders, and aims to develop organelle-targeted therapeutic strategies based on these insights. The laboratory has established a cross-disciplinary technological platform centered on electrophysiology, organelle biology, and high-throughput genetic and chemical screening, which provides a unique research advantage. The main research directions include: (1) the physiological and pathological implications of lysosomal mechanosensation and osmotic regulation; (2) molecular identification and functional characterization of novel organellar ion channels; and (3) development of small-molecule compounds, peptide drugs, and nanobodies targeting ion channels.

Full List of Publications Can Be Found Here